RT Journal Article
T1 Allergy to human seminal fluid: Cross-reactivity with dog dander
A1 Basagaña, María
A1 Bartolomé, Borja
A1 Pastor Vargas, Carlos
A1 Torres, Ferrán
A1 Alonso, Rosario
A1 Vivanco Martínez, Fernando
A1 Cisteró-Bahíma, Anna
AB Background: Human seminal plasma (HSP) allergy is uncommon, with symptoms ranging from vulvovaginal pruritus to life-threatening anaphylaxis. Although several seminal plasma allergens have been reported and their molecular masses have been estimated to range between 12 and 75 kd, the prostate-specific antigen (PSA) has recently been identified as a causative allergen. Given that in a large number of cases symptoms appeared during or after the first intercourse, a cross-reactivity phenomenon might be implicated.Objective: We sought to assess the presence of IgE cross-reactivity among proteins from dog epithelium and HSP and to attempt to identify the allergens involved.Methods: Forty-one patients with dog epithelium allergy were selected. One of them experienced anaphylaxis in contact with her husband's seminal plasma. Skin prick tests, serum specific IgE measurements, SDS-PAGE immunoblotting, and inhibition tests were performed to study the pattern of IgE-binding proteins and the potential cross-reactivity between HSP and dog epithelium. Mass spectrometry was carried out to identify the protein involved in allergy reactions.Results: Twenty-four percent of the sera from patients with dog epithelium allergy recognized an IgE-binding band of 28 kd in HSP immunoblotting. Mass spectrometry identified this band as the PSA. SDS-PAGE immunoblotting-inhibition showed a complete IgE-binding inhibition when sera from these patients were preincubated with dog dander extract.Conclusions: IgE cross-reactivity among proteins from dog dander and human PSA is demonstrated.
PB Elsevier
SN 0091-6749
YR 2008
FD 2008
LK https://hdl.handle.net/20.500.14352/95081
UL https://hdl.handle.net/20.500.14352/95081
LA eng
NO Basagaña M, Bartolomé B, Pastor C, Torres F, Alonso R, Vivanco F, Cisteró-Bahíma A. Allergy to human seminal fluid: cross-reactivity with dog dander. J Allergy Clin Immunol. 2008 Jan;121(1):233-9. doi: 10.1016/j.jaci.2007.10.008. Epub 2007 Dec 3. PMID: 18061650.
DS Docta Complutense
RD 6 abr 2025