RT Journal Article
T1 Effect of diinosine polyphosphates on intraocular pressure in normotensive rabbits
A1 Guzmán Aránguez, Ana Isabel
A1 Díez, Laura María
A1 Martín Gil, Alba
A1 Gualix Sánchez, Francisco Javier
A1 Miras Portugal, María Teresa
A1 Pintor Just, Jesús Jerónimo
AB The ability of diinosine polyphosphates, diinosine triphosphate (Ip 3I), diinosine tetraphosphate (Ip 4I) and diinosine pentaphosphate (Ip 5I) to modify intraocular pressure in normotensive New Zealand white rabbits was tested. Ip 5I produced increase in intraocular pressure, while Ip 3I and Ip 4I produced a decrease. Ip 4I was the most effective reducing intraocular pressure inducing a maximal decrease of intraocular pressure to 74.2 ± 2.5% compared with the control value. Dose-response analysis demonstrated a concentration dependent pattern which presented a pD 2 value of 6.19 ± 0.18, equivalent to an EC 50 of 0.63 μM. Regarding the underlying mechanism used by Ip 4I to reduce intraocular pressure, studies with agonists and antagonists revealed that Ip 4I reduces intraocular pressure via P2Y receptors in the eye. We suggest that topical application of Ip 4I to the cornea has therapeutic potential for lowering intraocular pressure, a major risk factor for glaucoma.
PB Elsevier
SN 0014-4835
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/101309
UL https://hdl.handle.net/20.500.14352/101309
LA eng
NO Guzman-Aranguez, Ana, et al. «Effect of Diinosine Polyphosphates on Intraocular Pressure in Normotensive Rabbits». Experimental Eye Research, vol. 101, agosto de 2012, pp. 49-55. https://doi.org/10.1016/j.exer.2012.05.011.
NO Ministerio de Ciencia e Innovación (España)
NO Red de Patologia ocular del envejecimiento, calidad visual y calidad de vida
NO NEUROTRANS CM
NO Bioquimica Farmacologica del ojo (OCUPHARM)
DS Docta Complutense
RD 21 abr 2025