RT Journal Article
T1 Phosphorogenic dipyrrinato-iridium(III) complexes as photosensitizers for photodynamic therapy
A1 Prieto Castañeda, Alejandro
A1 Lérida Viso, Araceli
A1 Avellanal Zaballa, Edurne
A1 Sola Llano, Rebeca
A1 Bañuelos, Jorge
A1 Rodríguez Agarrabeitia, Antonia
A1 Martínez Mañez, Ramon
A1 Ortiz García, María Josefa
AB We have designed and synthesized a family of Ir(III) metal complexes coordinated with two cyclometalated bisfluorophenylpyridine ligands and an ancillary dipyrromethene which is functionalized with a mesityl group (Ir(dipy)-1), an α-chloroacetyl ester (Ir(dipy)-2) or a chain containing an ammonium cation (Ir(dipy)-3). The Ir (III) complexes feature a high triplet state population enabling red phosphorescence and efficient singlet oxygen generation. Ir(dipy)-2 and Ir(dipy)-3 are demonstrated to stain cells in both one-photon and two-photon confocal imaging. Moreover, Ir(dipy)-2 and Ir(dipy)-3 produce ROS in cells upon irradiation, inducing cell death by apoptosis. Colocalization studies in SK-Mel-103 cells show that Ir(dipy)-3 is partially accumulated in mitochondria and induces upon irradiation a disruption in their morphology. Overall our studies demonstrate that the prepared Ir(III) act as photosensitizers able to kill cells under irradiation, being suitable candidates for photodynamic therapy applications.
PB Elsevier
SN 0143-7208
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/95843
UL https://hdl.handle.net/20.500.14352/95843
LA eng
NO Prieto-Castañeda, A.; Lérida-Viso, A.; Avellanal-Zaballa, E.; Sola-Llano, R.; Bañuelos, J.; Agarrabeitia, A.R.; Martínez-Mañez, R.; Ortiz, M.J., Dyes Pigment. 2022, 197, 10988602
NO Ministerio de Economía y Competitividad (España)
NO Eusko Jaurlaritza
DS Docta Complutense
RD 18 dic 2025