RT Journal Article
T1 Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae
A1 Søndergaard, Annette
A1 San Millan, Alvaro
A1 Santos López, Alfonso
A1 Nielsen, Signe M
A1 González Zorn, Bruno
A1 Nørskov-Lauritsen, Niels
AB TEM-1 is the dominant β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 carries a Tn3 resolvase gene and pA1606 and pA1209 carry an open reading frame (ORF) similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.
PB American Society for Microbiology
SN 1098-6596
YR 2012
FD 2012-09
LK https://hdl.handle.net/20.500.14352/45168
UL https://hdl.handle.net/20.500.14352/45168
LA eng
DS Docta Complutense
RD 17 abr 2025