RT Journal Article
T1 Measuring hemoglobin levels in the optic nerve head: Comparisons with other structural and functional parameters of glaucoma
A1 de la Rosa, M.G
A1 Gonzalez Hernandez, M
A1 Sigut, J
A1 Alayon, S
A1 Radcliffe, N
A1 Mendez Hernandez, C
A1 Méndez Hernández, Carmen Dora
A1 García Feijoo, Julián
A1 Fuertes Lazaro, I
A1 Perez Olivan, S
A1 Ferreras, A
AB PURPOSE. We evaluated and compared the ability of a new method for measuring hemoglobin (Hb) levels at the optic nerve head (ONH) to that of visual field evaluation, scanning laser ophthalmoscopy (HRT), scanning laser polarimetry (GDx), and optical coherence tomography (OCT) for diagnosing glaucoma. METHODS. Healthy eyes (n = 102) and glaucomatous eyes (n = 101) underwent reliable Oculus Spark perimetry, and imaging with the HRT, GDx, and Cirrus OCT. In addition, ONH color images were acquired with a non-mydriatic fundus camera. The Laguna ONhE program then was used to calculate the Hb amount in each of 24 sectors of the ONH. Sensitivities at 95% fixed specificity, diagnostic agreement, and linear correlations between parameters with the best diagnostic ability were calculated. RESULTS. The glaucoma discriminant function (GDF) of the Laguna program, evaluating Hb in the vertical intermediate sectors and center/periphery Hb amount slope, yielded an 89.1% sensitivity and 95.1% specificity, which was superior or similar to the other tests. The best GDF diagnostic agreement was for the OCT-vertical cup-to-disc (C/D) ratio (kappa = 0.772) and the final phase Spark pattern SD (kappa = 0.672). Hb levels correlated strongly with the Spark mean sensitivity (first phase 0.70, final phase 0.71). Hb also correlated well with the Reinhard OW Burk discriminant function of the HRT (0.56), nerve fiber indicator of GDx (-0.64), and vertical C/D ratio of OCT (0.71). CONCLUSIONS. Hb levels evaluated by color analysis of ONH photographs had high reproducibility, a high sensitivity- specificity balance, and moderate to strong agreement with other structural and functional tests. Copyright 2013 The Association for Research in Vision and Ophthalmology, Inc.
PB The Association for Research in Vision and Ophthalmology, Inc
YR 2013
FD 2013-01
LK https://hdl.handle.net/20.500.14352/107363
UL https://hdl.handle.net/20.500.14352/107363
LA eng
NO Agencia Canaria de Investigación, Innovación y Sociedad de la Información
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 22 ago 2024