RT Journal Article
T1 Fibrotic Events in the Progression of Cholestatic Liver Disease
A1 Wu, Hanghang
A1 Wu, Hanghang
A1 Chen, Chaobo
A1 Ziani, Siham
A1 Nelson, Leonard J
A1 Ávila, Matías A
A1 Nevzorova, Yulia
A1 Cubero Palero, Francisco Javier
AB Cholestatic liver diseases including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are associated with active hepatic fibrogenesis, which can ultimately lead to the development of cirrhosis. However, the exact relationship between the development of liver fibrosis and the progression of cholestatic liver disease remains elusive. Periductular fibroblasts located around the bile ducts seem biologically different from hepatic stellate cells (HSCs). The fibrotic events in these clinical conditions appear to be related to complex crosstalk between immune/inflammatory mechanisms, cytokine signalling, and perturbed homeostasis between cholangiocytes and mesenchymal cells. Several animal models including bile duct ligation (BDL) and the Mdr2knockout mice have improved our understanding of mechanisms underlying chronic cholestasis. In the present review, we aim to elucidate the mechanisms of fibrosis in order to help to identify potential diagnostic and therapeutic targets.
PB MDPI
SN 2073-4409
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/102069
UL https://hdl.handle.net/20.500.14352/102069
LA eng
NO Wu H, Chen C, Ziani S, Nelson LJ, Ávila MA, Nevzorova YA, Cubero FJ. Fibrotic Events in the Progression of Cholestatic Liver Disease. Cells. 2021 May 5;10(5):1107. doi: 10.3390/cells10051107. PMID: 34062960; PMCID: PMC8147992.
NO Cholestatic liver diseases including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are associated with active hepatic fibrogenesis, which can ultimately lead to the development of cirrhosis. However, the exact relationship between the development of liver fibrosis and the progression of cholestatic liver disease remains elusive. Periductular fibroblasts located around the bile ducts seem biologically different from hepatic stellate cells (HSCs). The fibrotic events in these clinical conditions appear to be related to complex crosstalk between immune/inflammatory mechanisms, cytokine signalling, and perturbed homeostasis between cholangiocytes and mesenchymal cells. Several animal models including bile duct ligation (BDL) and the Mdr2-knockout mice have improved our understanding of mechanisms underlying chronic cholestasis. In the present review, we aim to elucidate the mechanisms of fibrosis in order to help to identify potential diagnostic and therapeutic targets.
NO Ministerio de Economía, Comercio y Empresa
NO German Research Foundation
DS Docta Complutense
RD 20 jul 2024