RT Journal Article
T1 Pregnancy and orthotopic liver transplantation
A1 Álvaro, Edurne
A1 Jiménez Romero, Luis Carlos
A1 Palomo, Ignacio
A1 Manrique Municio, Alejandro
A1 Alegre, Cristina
A1 García, María
A1 Justo Alonso, Iago
A1 Abradelo De Usera, Manuel
A1 Calvo Pulido, Jorge
A1 García-Sesma Pérez-Fuentes, Álvaro
A1 Cambra Molero, Félix
A1 Loinaz Segurola, Carmelo
A1 Moreno González, Enrique
AB BackgroundSexual and reproductive abnormalities affect up to 50% patients with terminal liver failure. However, these functions recover quickly after orthotopic liver transplantation (OLT). Thus, 80%–90% of OLT women of childbearing age recover menstruation within a few months after transplantation. The aim of our study was to analyze the impact of pregnancy among liver transplant recipients at our center, as well as to analyze the effects of immunosuppression on the fetus.MethodsFrom April 1986 to April 2011, we performed 1500 OLT in 1341 recipients. Among these recipients, 18 patients (1.2%) become pregnant during the follow-up.ResultsThe most frequent causes of terminal liver failure were as follows: chronic parenchymal disease (n = 9; 50%), cholestatic disease (n = 3; 16.6%), acute liver failure (n = 5; 27.7%), and metabolic disease (n = 1; 5.5%) The average recipient age at the beginning of pregnancy was 21.2 (±7.3) years. Sixteen patients (88%) became pregnant beyond a year after OLT. The 30 pregnancies in our study resulted in the following: newborns alive (NBA; n = 20; 66.6%) abortions (n = 8; 26.6%) or fetal deaths (n = 2; 6%). The most common immunosuppressant used during pregnancy was tacrolimus (75%) followed by cyclosporine (25%). There were no maternal deaths during pregnancy or the postpartum period.DiscussionWe did not observe significant differences between immunosuppression type and maternal complications, pregnancy duration, and childbirth type. Although pregnancy is potential risk, the literature and our results suggest that at a year or more after OLT it usually is safe and successful.
PB Elsevier
SN 0041-1345
YR 2013
FD 2013-06-13
LK https://hdl.handle.net/20.500.14352/116749
UL https://hdl.handle.net/20.500.14352/116749
LA eng
NO E Alvaro 1, L C Jimenez, I Palomo, A Manrique, C Alegre, M Garcia, I Justo, M Abradelo, J Calvo, A Garcia-Sesma, F Cambra, C Loinaz, E Moreno. Pregnancy and orthotopic liver transplantation. Transplant Proc . 2013 Jun;45(5):1966-8.
DS Docta Complutense
RD 8 abr 2025