RT Journal Article
T1 Eficacia del trasplante de células madre mesenquimales de lipoaspirado en el tratamiento de lesiones crónicas del manguito rotador. Modelo experimental en ratas
T2 Efficacy of transplantation of lipoaspired mesenchymal stem cells in the treatment of chronic rotator cuff tears. Experimental model in rats
A1 Ponz Lueza, Virginia
A1 Lópiz Morales, María Yaiza
A1 Rodríguez Bobada, María Cruz
A1 Tornero Esteban, Pilar
A1 Arvinius, Camila
A1 García Fernández, Carlos
A1 Seara Lifante, D.
A1 Rojo Pérez, Francisco Javier
A1 Marco Martínez, Fernando
AB Background and aim: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a Cellular Therapy Drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury.Material and methods: The supraspinatus lesion was created in 48 rats for subsequent suturing at 4 weeks. MSCs in suspension were added to 24 animals after suturing, and HypoThermosol-FRS® (HTS) to 24 animals as a control group. Histology (Åström and Rausing scale) and the maximum load, displacement and elastic constant of the supraspinatus tendon were analyzed in both groups 4 months after the repair.Results: No statistically significant differences were found in the histological score comparing the tendons treated with MSCs with respect to the tendons treated with HTS (P=.811) nor in the results of maximum load (P=.770), displacement (P=.852) or elastic constant (P=.669) of the tendon in both groups.Conclusions: The addition of adipose-derived cells in suspension to the repair of a chronic cuff injury does not improve the histology or biomechanics of the sutured tendon.
PB Elsevier
SN 1888-4415
YR 2024
FD 2024-01-01
LK https://hdl.handle.net/20.500.14352/107476
UL https://hdl.handle.net/20.500.14352/107476
LA eng
NO Ponz-Lueza V, Lopiz Y, Rodríguez-Bobada C, Tornero-Esteban P, Arvinius C, García-Fernández C, Seara-Lifante D, Rojo-Pérez FJ, Marco F. Efficacy of transplantation of lipoaspired mesenchymal stem cells in the treatment of chronic rotator cuff tears. Experimental model in rats. Rev Esp Cir Ortop Traumatol. 2024 Jan-Feb;68(1):9-17. English, Spanish. doi: 10.1016/j.recot.2023.05.006. Epub 2023 May 23. PMID: 37230410.
NO Instituto Carlos III
DS Docta Complutense
RD 8 sept 2024