RT Journal Article
T1 A 3D Peptide/[60]Fullerene hybrid for multivalent recognition
A1 Gallego, Iván
A1 Ramos‐Soriano, Javier
A1 Méndez‐Ardoy, Alejandro
A1 Cabrera González, Justo Enrique
A1 Lostalé‐Seijo, Irene
A1 Illescas Martínez, Beatriz María
A1 Martín León, Nazario
A1 Reina, Jose
A1 Montenegro, Javier
AB Fully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis‐adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E‐selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.
PB Wiley
SN 0044-8249
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/92739
UL https://hdl.handle.net/20.500.14352/92739
LA eng
NO Gallego, Iván, et al. «A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition». Angewandte Chemie International Edition, vol. 61, n.o 41, octubre de 2022, p. e202210043. https://doi.org/10.1002/anie.202210043.
NO Xunta de Galicia
NO European Commission
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 6 oct 2024