RT Journal Article
T1 Oxidative stress and metabolism: A mechanistic insight for glyphosate toxicology
A1 Wang, Xiaojing
A1 Lu, Qirong
A1 Guo, Jingchao
A1 Ares Lombán, Irma
A1 Martínez Caballero, Marta
A1 Martínez Larrañaga, María Rosa
A1 Wang, Xu
A1 Anadón Navarro, Arturo Ramón
A1 Martínez Caballero, María Aranzazu
AB Glyphosate (GLYP) is a widely used pesticide; it is considered to be a safe herbicide for animals and humans because it targets 5-enolpyruvylshikimate-3-phosphate synthase. However, there has been increasing evidence that GLYP causes varying degrees of toxicity. Moreover, oxidative stress and metabolism are highly correlated with toxicity. This review provides a comprehensive introduction to the toxicity of GLYP and, for the first time, systematically summarizes the toxicity mechanism of GLYP from the perspective of oxidative stress, including GLYP-mediated oxidative damage, changes in antioxidant status, altered signaling pathways, and the regulation of oxidative stress by exogenous substances. In addition, the metabolism of GLYP is discussed, including metabolites,metabolic pathways, metabolic enzymes, and the toxicity of metabolites. This review provides new ideas for the toxicity mechanism of GLYP and proposes effective strategies for reducing its toxicity.
PB Annual Reviews
SN 1545-4304
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/97293
UL https://hdl.handle.net/20.500.14352/97293
LA eng
NO Wang X, Lu Q, Guo J, Ares I, Martínez M, Martínez-Larrañaga MR, Wang X, Anadón A, Martínez MA. Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology. Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:617-639. doi: 10.1146/annurev-pharmtox-020821-111552. PMID: 34990202.
NO National Key Research and Development Program of China
NO Fundamental Research Funds for the Central Universities
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 20 abr 2025