RT Journal Article
T1 Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure
A1 Heras Jiménez, Natalia De Las
A1 Galiana, Adrián
A1 Ballesteros Rodrigálvarez, Sandra
A1 Olivares Álvaro, Elena
A1 Fuller, Peter J.
A1 Lahera Julia, Vicente
A1 Martín Fernández, Beatriz
A1 Ballesteros Rodrigálvarez, Sandra María
AB Excess aldosterone promotes pathological remodeling of the heart and imbalance in cardiac ion homeostasis of sodium, potassium and calcium. Novel treatment with proanthocyanidins in aldosterone-treated rats has resulted in downregulation of cardiac SGK1, the main genomic aldosterone-induced intracellular mediator of ion handling. It therefore follows that proanthocyanidins could be modulating cardiac ion homeostasis in aldosterone-treated rats. Male Wistar rats received aldosterone (1 mg kg−1 day−1) +1% NaCl for three weeks. Half of the animals in each group were simultaneously treated with the proanthocyanidins-rich extract (80% w/w) (PRO80, 5 mg kg−1 day−1). PRO80 prevented cardiac hypertrophy and decreased calcium content. Expression of ion channels (ROMK, NHE1, NKA and NCX1) and calcium transient mediators (CAV1.2, pCaMKII and oxCaMKII) were reduced by PRO80 treatment in aldosterone-treated rats. To conclude, our data indicate that PRO80 may offer an alternative treatment to conventional MR-blockade in the prevention of aldosterone-induced cardiac pathology.
PB MPDI
SN 1422-0067
YR 2021
FD 2021-09-04
LK https://hdl.handle.net/20.500.14352/4841
UL https://hdl.handle.net/20.500.14352/4841
LA eng
NO Heras Jiménez, N., Galiana, A., Ballesteros Rodigálvarez, S. et al. «Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure». International Journal of Molecular Sciences, vol. 22, n.o 17, septiembre de 2021, p. 9602. DOI.org (Crossref), https://doi.org/10.3390/ijms22179602.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Universidad de León
DS Docta Complutense
RD 4 abr 2025