RT Journal Article
T1 Telomerase Is Essential for Zebrafish Heart Regeneration
A1 Bednarek, Dorota
A1 González Rosa, Juan Manuel
A1 Guzmán Martínez, Gabriela
A1 Gutiérrez Gutiérrez, Óscar
A1 Aguado, Tania
A1 Sánchez Ferrer, Carlota
A1 Joao Marques, Ines
A1 Galardi Castilla, María
A1 Diego, Irene de
A1 Gómez, Manuel José
A1 Cortés Rubio, José Alfonso
A1 Zapata González, Agustín
A1 Jiménez Borreguero, Luis Jesús
A1 Mercader, Nadia
A1 Flores, Ignacio
AB After myocardial infarction in humans, lost cardiomyocytes are replaced by an irreversible fibrotic scar. In contrast, zebrafish hearts efficiently regenerate after injury. Complete regeneration of the zebrafish heart is driven by the strong proliferation response of its cardiomyocytes to injury. Here we show that, after cardiac injury in zebrafish, telomerase becomes hyperactivated, and telomeres elongate transiently, preceding a peak of cardiomyocyte proliferation and full organ recovery. Using a telomerase-mutant zebrafish model, we found that telomerase loss drastically decreases cardiomyocyte proliferation and fibrotic tissue regression after cryoinjury and that cardiac function does not recover. The impaired cardiomyocyte proliferation response is accompanied by the absence of cardiomyocytes with long telomeres and an increased proportion of cardiomyocytes showing DNA damage and senescence characteristics. These findings demonstrate the importance of telomerase function in heart regeneration and highlight the potential of telomerase therapy as a means of stimulating cell proliferation upon myocardial infarction.
PB Cross Mark
SN 2211-1247
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/35557
UL https://hdl.handle.net/20.500.14352/35557
LA eng
NO Bednarek D, González-Rosa JM, Guzmán-Martínez G, Gutiérrez-Gutiérrez Ó, Aguado T, Sánchez-Ferrer C, et al. Telomerase Is Essential for Zebrafish Heart Regeneration. Cell Reports 2015;12:1691–703. https://doi.org/10.1016/j.celrep.2015.07.064.
NO Unión Europea. FP7
NO Ministerio de Economía, Comercio y Empresa (España)
NO Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (España)
DS Docta Complutense
RD 5 abr 2025