RT Journal Article
T1 Drug Release from Ordered Mesoporous Silicas
A1 Doadrio Villarejo, Antonio Luis
A1 Salinas Sánchez, Antonio Jesús
A1 Sánchez Montero, José
A1 Vallet Regí, María Dulce Nombre
AB The state-of-the-art in the investigation of drugs release from Silica-based ordered Mesoporous Materials (SMMs) is reviewed. First, the SMM systems used like host matrixes are described. Then, the model drugs studied until now, including their pharmacological action, structure and the mesoporous matrix employed for each drug, are comprehensively listed. Next, the factors influencing the release of drugs from SMMs and the strategies used to control the drug delivery, specially the chemical functionalization of the silica surface, are discussed. In addition, how all these factors were gathered in a kinetic equation that describes the drug release from the mesoporous matrixes is explained. The new application of molecular modeling and docking in the investigation of the drug delivery mechanisms from SMMs is also presented. Finally, the new approaches under investigation in this field are mentioned including the design of smart stimuli-responsive materials and other recent proposals for a future investigation.
PB Bentham Science Publishers
SN 1381-6128
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/35407
UL https://hdl.handle.net/20.500.14352/35407
LA eng
NO RESEARCH ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCH ID M-3316-2014 (Antonio Salinas Sánchez)ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)ORCID: 0000-0001-8380-4781 (Antonio Doadrio Villarejo)
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Economía, Comercio y Empresa (España)
NO European Network of Excellence
DS Docta Complutense
RD 7 abr 2025