RT Journal Article
T1 Intrathymic selection and defects in the thymicepithelial cell development
A1 Garcia-Ceca Hernández, Javier
A1 Montero Herradón, Sara
A1 Zapata González, Agustín
AB Intimate interactions between thymic epithelial cells (TECs) and thymocytes (T) have been repeatedly reported as essential for performing intrathymic T-cell education. Nevertheless, it has been described that animals exhibiting defects in these interactions were capable of a proper positive and negative T-cell selection. In the current review, we first examined distinct types of TECs and their possible role in the immune surveillance. However, EphB-deficient thymi that exhibit profound thymic epithelial (TE) alterations do not exhibit important immunological defects. Eph and their ligands, the ephrins, are implicated in cell attachment/detachment and govern, therefore, TEC–T interactions. On this basis, we hypothesized that a few normal TE areas could be enough for a proper phenotypical and functional maturation of T lymphocytes. Then, we evaluated in vivo how many TECs would be necessary for supporting a normal T-cell differentiation, concluding that a significantly low number of TEC are still capable of supporting normal T lymphocyte maturation, whereas with fewer numbers, T-cell maturation is not possible.
PB MDPI
SN 2073-4409
YR 2020
FD 2020-10-02
LK https://hdl.handle.net/20.500.14352/7948
UL https://hdl.handle.net/20.500.14352/7948
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Comunidad de Madrid
NO Instituto de Salud Carlos III (ISCIII)
DS Docta Complutense
RD 6 abr 2025