RT Journal Article
T1 Broad virus inactivation using inorganic micro/nano-particulate materials
A1 Rius-Rocabert, Sergio
A1 Arranz-Herrero, Javier
A1 Fernández-Valdés, Adolfo
A1 Marciello, Marzia
A1 Moreno, Sandra
A1 Llinares-Pinel, Francisco
A1 Presa, Jesús
A1 Hernandez-Alcoceba, Rubén
A1 López-Píriz, Roberto
A1 Torrecillas, Ramón
A1 García, Antonia
A1 Brun, Alejandro
A1 Filice, Marco
A1 Moya, José S.
A1 Cabal, Belen
A1 Nistal-Villan, Estanislao
AB Inorganic materials can provide a set of tools to decontaminate solid, liquid or air containing viral particles. The use of disinfectants can be limited or not practical in scenarios where continuous cleaning is not feasible. Physicochemical differences between viruses raise the need for effective formulations for all kind of viruses. In the present work we describe two types of antimicrobial inorganic materials: i) a novel soda-lime glass (G3), and ii) kaolin containing metals nanoparticles (Ag or CuO), as materials to disable virus infectivity. Strong antiviral properties can be observed in G3 glass, and kaolin-containing nanoparticle materials showing a reduction of viral infectivity close to 99% in the first 10 ​min of contact of vesicular stomatitis virus (VSV). A potent virucidal activity is also present in G3 and kaolin containing Ag or CuO nanoparticles against all kinds of viruses tested, reducing more than 99% the amount of HSV-1, Adenovirus, VSV, Influenza virus and SARS-CoV-2 exposed to them. Virucidal properties could be explained by a direct interaction of materials with viruses as well as inactivation by the presence of virucidal elements in the material lixiviates. Kaolin-based materials guarantee a controlled release of active nanoparticles with antiviral activity. Current coronavirus crisis highlights the need for new strategies to remove viruses from contaminated areas. We propose these low-cost inorganic materials as useful disinfecting antivirals in the actual or future pandemic threats.
SN 2590-0064
YR 2022
FD 2022-01
LK https://hdl.handle.net/20.500.14352/100702
UL https://hdl.handle.net/20.500.14352/100702
LA eng
NO Rius-Rocabert S, Arranz-Herrero J, Fernández-Valdés A, Marciello M, Moreno S, Llinares-Pinel F, et al. Broad virus inactivation using inorganic micro/nano-particulate materials. Materials Today Bio 2022;13:100191. https://doi.org/10.1016/j.mtbio.2021.100191.
NO Consejo Superior de Investigaciones Científicas
NO Comunidad de Madrid
NO Universidad Complutense de Madrid
NO European Virus Archive GLOBAL
NO European Union's Horizon 2020
NO Universidad San Pablo CEU
NO Federación Española de Enfermedades Raras
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 7 abr 2025