RT Journal Article
T1 Gestational and lactational lead intoxication produces alterations in the hepatic system of rat pups
A1 Corpas Vázquez, María Isabel
A1 Benito, María J.
A1 Marquina Díaz, Domingo
A1 Castillo, Manuela
A1 López, Noelia
A1 Antonio García, María Teresa
AB The effects of lead (Pb) intoxication during pregnancy and lactation were studied in the hepatic system of pups and young Wistar rats to test the hypothesis that gestational and lactational lead exposure alters the normal function of the liver in neonates. Lead acetate (300 mg/L) dissolved in distilled water was administered ad libitum to mothers during gestation and lactation. At days 12 and 21 postnatal (PN), pups were sacrificed, blood was collected, and livers were removed. Blood lead (PbB) levels were also measured. Although, histological evaluation revealed neither abnormalities in the liver structure nor depositions of lead, the toxicant produced biochemical alterations. Lead-intoxicated pups exhibited a decrease in hemoglobin, iron, and alkaline and acid phosphatase levels and an increase in PbB content. Protein, DNA, and lipid total amounts were reduced, and hepatic glycogen content was diminished at days 12 and 21 PN, with a higher level of glucose in the blood. Lead administration also resulted in a decrease in alkaline phosphatase in the liver of pups at day 21 PN, but acid phosphatase was unaltered. The findings of this study support the hypothesis that lead intoxication of mothers in gestation and lactation results in alterations in the hepatic system in neonates and pups.
PB Elsevier
SN 0147-6513
YR 2002
FD 2002-01
LK https://hdl.handle.net/20.500.14352/108228
UL https://hdl.handle.net/20.500.14352/108228
LA eng
NO Corpas, Isabel, et al. «Gestational and Lactational Lead Intoxication Produces Alterations in the Hepatic System of Rat Pups». Ecotoxicology and Environmental Safety, vol. 51, n.o 1, enero de 2002, pp. 35-43. DOI.org (Crossref), https://doi.org/10.1006/eesa.2001.2102.
DS Docta Complutense
RD 25 abr 2025