RT Journal Article
T1 Dictionary-based software for proton dose reconstruction and submilimetric range verification
A1 Valladolid Onecha, Víctor
A1 Galve Lahoz, Pablo
A1 Ibáñez García, Paula Beatriz
A1 Freijo Escudero, Clara
A1 Arias Valcayo, Fernando
A1 Sánchez Parcerisa, Daniel
A1 España Palomares, Samuel
A1 Fraile Prieto, Luis Mario
A1 Udías Moinelo, José Manuel
AB Objective. This paper presents a new method for fast reconstruction (compatible with in-beam use) of deposited dose during proton therapy using data acquired from a PET scanner. The most innovative feature of this novel method is the production of noiseless reconstructed dose distributions from which proton range can be derived with high precision. Approach. A new MLEM & simulated annealing (MSA) algorithm, developed especially in this work, reconstructs the deposited dose distribution from a realistic pre-calculated activity-dose dictionary. This dictionary contains the contribution of each beam in the plan to the 3D activity and dose maps, as calculated by a Monte Carlo simulation. The MSA algorithm, using a priori information of the treatment plan, seeks for the linear combination of activities of the precomputed beams that best fits the observed PET data, obtaining at the same time the deposited dose. Main results. the method has been tested using simulated data to determine its performance under 4 different test cases: (1) dependency of range detection accuracy with delivered dose, (2) in-beam versus offline verification, (3) ability to detect anatomical changes and (4) reconstruction of a realistic spread-out Bragg peak. The results show the ability of the method to accurately reconstruct doses from PET data corresponding to 1 Gy irradiations, both in intra-fraction and inter-fraction verification scenarios. For this dose level (1 Gy) the method was able to spot range variations as small as 0.6 mm. Significance. out method is able to reconstruct dose maps with remarkable accuracy from clinically relevant dose levels down to 1 Gy. Furthermore, due to the noiseless nature of reconstructed dose maps, an accuracy better than one millimeter was obtained in proton range estimates. These features make of this method a realistic option for range verification in proton therapy.
PB IOP Publishing
SN 0031-9155
YR 2022
FD 2022-02-09
LK https://hdl.handle.net/20.500.14352/134761
UL https://hdl.handle.net/20.500.14352/134761
LA eng
NO Onecha V V, Galve P, Ibáñez P, Freijo C, Arias-Valcayo F, Sanchez-Parcerisa D, España S, Fraile L M and Udías J M 2022 Dictionary-based software for proton dose reconstruction and submilimetric range verification Phys. Med. Biol. 67 045002 Online: https://iopscience.iop.org/article/10.1088/1361-6560/ac4efc
NO ©2022 Institute of Physics and Engineering in Medicine
DS Docta Complutense
RD 28 abr 2026