RT Journal Article
T1 Non-Invasive Breast Cancer Diagnosis through Electrochemical Biosensing at Different Molecular Levels
A1 Campuzano, Susana
A1 Pedrero Muñoz, María
A1 Pingarrón Carrazón, José Manuel
AB The rapid and accurate determination of specific circulating biomarkers at different molecular levels with non- or minimally invasive methods constitutes a major challenge to improve the breast cancer outcomes and life quality of patients. In this field, electrochemical biosensors have demonstrated to be promising alternatives against more complex conventional strategies to perform fast, accurate and on-site determination of circulating biomarkers at low concentrations in minimally treated body fluids. In this article, after discussing briefly the relevance and current challenges associated with the determination of breast cancer circulating biomarkers, an updated overview of the electrochemical affinity biosensing strategies emerged in the last 5 years for this purpose is provided highlighting the great potentiality of these methodologies. After critically discussing the most interesting features of the electrochemical strategies reported so far for the single or multiplexed determination of such biomarkers with demonstrated applicability in liquid biopsy analysis, existing challenges still to be addressed and future directions in this field will be pointed out.
PB MDPI
SN 1424-8220
YR 2017
FD 2017-09
LK https://hdl.handle.net/20.500.14352/18095
UL https://hdl.handle.net/20.500.14352/18095
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
DS Docta Complutense
RD 20 ago 2024