RT Journal Article
T1 Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge
A1 Acaz Fonseca, Estefanía
A1 Ortiz Rodriguez, Ana
A1 Azcoitia Elías, Iñigo
A1 García-Segura, Luis Miguel
A1 Arévalo, María Ángeles
AB In the nervous system, Notch pathway has a prominent role in the control of neuronal morphology and in the determination of the astrocyte fate. However, the role of Notch in morphological astrocyte plasticity is unknown. Here, we have explored the role of Notch activity on the morphological reactivity of primary astrocytes in response to LPS, an inflammatory stimulus. We found that LPS induces reactive astrocyte morphology by the inhibition of Notch signaling via NFκB activation and Jagged upregulation. In contrast, IGF-1, an anti-inflammatory molecule, inhibits LPS-induced reactive astrocyte morphological phenotype by enhancing Notch signaling through the inhibition of NFκB and the activation of MAPK. Therefore, Notch signaling pathway emerges as a mediator of the regulation of astrocyte morphology by inflammatory and anti-inflammatory stimuli.
PB Springer
SN 2058-7716
YR 2019
FD 2019-04-03
LK https://hdl.handle.net/20.500.14352/13663
UL https://hdl.handle.net/20.500.14352/13663
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES)
NO Instituto de Salud Carlos III (ISCIII)/FEDER
DS Docta Complutense
RD 5 abr 2025