RT Journal Article
T1 A Transcriptomic Meta-Analysis Shows Lipid Metabolism Dysregulation as an Early Pathological Mechanism in the Spinal Cord of SOD1 Mice
A1 Fernández Beltrán, Luis Carlos
A1 Godoy Corchuelo, Juan Miguel
A1 Losa Fontangordo, Maria
A1 Williams, Debbie
A1 Matías-Guiu Guía, Jorge
A1 Corrochano, Silvia
AB Amyotrophic lateral sclerosis (ALS) is a multifactorial and complex fatal degenerative disorder. A number of pathological mechanisms that lead to motor neuron death have been identified, although there are many unknowns in the disease aetiology of ALS. Alterations in lipid metabolism are well documented in the progression of ALS, both at the systemic level and in the spinal cord of mouse models and ALS patients. The origin of these lipid alterations remains unclear. This study aims to identify early lipid metabolic pathways altered before systemic metabolic symptoms in the spinal cord of mouse models of ALS. To do this, we performed a transcriptomic analysis of the spinal cord of SOD1G93A mice at an early disease stage, followed by a robust transcriptomic meta-analysis using publicly available RNA-seq data from the spinal cord of SOD1 mice at early and late symptomatic disease stages. The meta-analyses identified few lipid metabolic pathways dysregulated early that were exacerbated at symptomatic stages; mainly cholesterol biosynthesis, ceramide catabolism, and eicosanoid synthesis pathways. We present an insight into the pathological mechanisms in ALS, confirming that lipid metabolic alterations are transcriptionally dysregulated and are central to ALS aetiology, opening new options for the treatment of these devastating conditions.
PB MDPI
SN 1422-0067
YR 2021
FD 2021-09-02
LK https://hdl.handle.net/20.500.14352/5045
UL https://hdl.handle.net/20.500.14352/5045
LA eng
NO Fernández Beltrán, L. C., Godoy Corchuelo, J. M., Losa Fontangordo, M. et al. «A Transcriptomic Meta-Analysis Shows Lipid Metabolism Dysregulation as an Early Pathological Mechanism in the Spinal Cord of SOD1 Mice». International Journal of Molecular Sciences, vol. 22, n.o 17, septiembre de 2021, p. 9553. DOI.org (Crossref), https://doi.org/10.3390/ijms22179553.
NO This research was funded by Consejería de Educación de la Comunidad de Madrid, through the Atracción de Talento program, grant number 2018-T1/BMD-10731
NO Comunidad de Madrid
DS Docta Complutense
RD 23 abr 2025