RT Journal Article T1 Red haloBODIPYs as theragnostic agents: The role of the substitution at meso position A1 Prieto Montero, Ruth A1 Prieto Castañeda, Alejandro A1 Katsumiti, Alberto A1 Sola Llano, Rebeca A1 Rodríguez Agarrabeitia, Antonia A1 Cajaraville, Miren P. A1 Ortiz García, María Josefa A1 Martínez Martínez, Virginia AB Three different molecular designs based on BODIPY dye have been proposed as photosensitizers (PSs) for photodynamic therapy (PDT) by the inclusion of halogen atoms (Iodine) at 2,6-positions and with extended conjugation at 3, 5-positions and varying the substitution at meso position. The synthesis is described and their main photophysical features including singlet oxygen production and triplet states were characterized by absorption and fluorescence spectroscopy (steady-state and time-correlated) and nanosecond transient absorption spectroscopy. The results were compared with the commercial Chlorin e6. The three new red-halogen-BODIPYs showed a great balance between singlet oxygen generation (ΦΔ≥0.40) and fluorescence (Φfl≥0.22) for potential application on PDT, and particularly in theragnosis. In vitro experiments in HeLa cells were done to study their performance and to elucidate the best potential candidate for PDT. PB Elsevier SN 0143-7208 YR 2021 FD 2021-12-04 LK https://hdl.handle.net/20.500.14352/4603 UL https://hdl.handle.net/20.500.14352/4603 LA eng NO Prieto Montero, R., Prieto Castañeda, A., Katsumiti, A. et al. «Red haloBODIPYs as Theragnostic Agents: The Role of the Substitution at Meso Position». Dyes and Pigments, vol. 198, febrero de 2022, p. 110015. DOI.org (Crossref), https://doi.org/10.1016/j.dyepig.2021.110015. NO Ministerio de Ciencia, Innovación y Universidades (España) NO Gobierno Vasco NO Universidad del País Vasco DS Docta Complutense RD 6 oct 2024