RT Journal Article
T1 PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
A1 Barber, Domingo
A1 Fernández Arias, Cristina
A1 Carrera, Ana
AB Systemic lupus erythematosus (SLE) is a chronic inflammatory disease generated by deregulation of T cell–mediated B-cell activation, which results in glomerulonephritis and renal failure. Disease is treated with immunosuppressants and cytostatic agents that have numerous side effects. Here we examine the use of inhibitors of phosphoinositide 3-kinase (PI3K) γ, a lipid kinase that regulates inflammation, in the MRL-lpr mouse model of SLE. Treatment reduced glomerulonephritis and prolonged lifespan, suggesting that P13Kγ may be a useful target in the treatment of chronic inflammation.
PB Nature Research
SN 1546-170X
YR 2005
FD 2005
LK https://hdl.handle.net/20.500.14352/96062
UL https://hdl.handle.net/20.500.14352/96062
LA eng
NO Barber, D., Bartolomé, A., Hernandez, C. et al. PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat Med 11, 933–935 (2005). https://doi.org/10.1038/nm1291
NO Fundación Ramón Areces
NO European Commission 
NO Comunidad Autónoma de Madrid
NO Ministerio de Ciencia e Innovación (España) 
DS Docta Complutense
RD 19 dic 2025