RT Journal Article T1 Association of Quadratus Lumborum Muscle Stiffness with Chronic Low Back Pain Features: An Observational Study A1 López Redondo, Mónica A1 Vicente Campos, Davinia A1 Álvarez González, Javier A1 Roldán Ruiz, Alberto A1 Sánchez Jorge, Sandra A1 Buffet García, Jorge A1 Rabanal Rodríguez, Gabriel A1 Valera Calero, Juan Antonio AB Background and Objectives: Low back pain (LBP) is highly prevalent and often associated with altered muscle function, including in the quadratus lumborum (QL) muscle. While some studies have highlighted the clinical relevance of QL muscle stiffness in LBP, the findings remain inconsistent, and the role of this parameter in relation to clinical severity indicators is not well understood. Considering the high prevalence of myofascial trigger points among patients, objectively and reliably quantifying QL stiffness and its association with other clinical parameters could improve the identification of early stages of the condition before other alterations become apparent. Therefore, this study aimed to explore the association between QL stiffness and multiple indicators of LBP severity. Materials and Methods: A cross-sectional observational study was conducted involving the participation of seventy-six patients suffering from chronic LBP. An ultrasound scanner with shear-wave elastography (SWE) was used to determine the participants’ QL stiffness. Additional information was collected on LBP-associated pain intensity, disability, central sensitization, and quality of life. Results: QL muscle stiffness was negatively correlated with pain intensity (p < 0.01) and central sensitization (p < 0.01), and it was positively correlated with physical quality of life (p < 0.01). Muscle stiffness influenced the variance in pain intensity along with physical quality of life, central sensitization, and chronicity (together explaining 49% of the variance) but did not explain the variance in central sensitization. Conclusions: Assessing QL muscle stiffness in patients with LBP is recommended, as greater muscle softness is linked to higher pain intensity, central sensitization, and poorer physical quality of life. Regression analyses further highlighted that QL stiffness helps explain the variance in pain intensity, physical quality of life, central sensitization, and chronicity, but it did not directly affect the central sensitization variance. PB Multidisciplinary Digital Publishing Institute (MDPI) SN 1648-9144 YR 2025 FD 2025-02-05 LK https://hdl.handle.net/20.500.14352/121707 UL https://hdl.handle.net/20.500.14352/121707 LA eng NO López-Redondo M, Vicente-Campos D, Álvarez-González J, Roldán-Ruiz A, Sánchez-Jorge S, Buffet-García J, et al. Association of Quadratus Lumborum Muscle Stiffness with Chronic Low Back Pain Features: An Observational Study. Medicina (Lithuania). 2025;61(2). NO Gabriel Rabanal-Rodríguez es beneficiario de una beca de formación para investigadores otorgada por la Universidad Complutense de Madrid y Banco Santander (CT25/24). DS Docta Complutense RD 31 dic 2025