RT Journal Article
T1 Manganese increases Aβ and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death following single and repeated treatment
A1 Moyano-Cires Ivanoff, Paula Viviana
A1 García Sánchez, José Manuel
A1 García Lobo, Jimena
A1 Anadón Baselga, María José
A1 Naval López, María Victoria
A1 Frejo Moya, María Teresa
A1 Sola Vendrell, Emma
A1 Pelayo Alarcón, Adela
A1 Pino Sans, Javier Del
AB Manganese (Mn) produces cholinergic neuronal loss in basal forebrain (BF) region that was related to cognitive dysfunction induced after single and repeated Mn treatment. All processes that generate cholinergic neuronal loss in BF remain to be understood. Mn exposure may produce the reduction of BF cholinergic neurons by increasing amyloid beta (Aβ) and phosphorylated Tau (pTau) protein levels, altering heat shock proteins’ (HSPs) expression, disrupting proteasome P20S activity and generating oxidative stress. These mechanisms, described to be altered by Mn in regions different than BF, could lead to the memory and learning process alteration produced after Mn exposure. The research performed shows that single and repeated Mn treatment of SN56 cholinergic neurons from BF induces P20S inhibition, increases Aβ and pTau protein levels, produces HSP90 and HSP70 proteins expression alteration, and oxidative stress generation, being the last two effects mediated by NRF2 pathway alteration. The increment of Aβ and pTau protein levels was mediated by HSPs and proteasome dysfunction. All these mechanisms mediated the cell decline observed after Mn treatment. Our results are relevant because they may assist to reveal the processes leading to the neurotoxicity and cognitive alterations observed after Mn exposure.
PB Elservier
SN 0147-6513
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/100524
UL https://hdl.handle.net/20.500.14352/100524
LA eng
NO Manganese increases Aβ and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death following single and repeated treatment. Moyano P, García JM, García J, Anadon MJ, Naval MV, Frejo MT, Sola E, Pelayo A, Pino JD. Ecotoxicology and Environmental Safety. 2020 Oct 15:203:110975
NO Banco Santander
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 11 abr 2025