RT Journal Article
T1 Sh(i)pping Signals Protect Against Stat3-Driven Liver Cancer
A1 Nevzorova, Yulia
A1 Liedtke, Christian
AB The human gene PTPN11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several types of leukemia. Herein we report a tumor-suppressor function of Shp2. Hepatocyte-specific deletion of Shp2 promotes inflammatory signaling through the Stat3 pathway and hepatic inflammation/necrosis, resulting in regenerative hyperplasia and development of tumors in aged mice. Furthermore, Shp2 ablation dramatically enhanced diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) development, which was abolished by concurrent deletion of Shp2 and Stat3 in hepatocytes. Decreased Shp2 expression was detected in a subfraction of human HCC specimens. Thus, in contrast to the leukemogenic effect of dominant-active mutants, Ptpn11/Shp2 has a tumor-suppressor function in liver.
PB Elsevier
YR 2011
FD 2011-12-21
LK https://hdl.handle.net/20.500.14352/98107
UL https://hdl.handle.net/20.500.14352/98107
LA eng
NO Nevzorova YA, Liedtke C. Sh(i)pping signals protect against Stat3-driven liver cancer. Hepatology. 2012 Jan;55(1):322-4. doi: 10.1002/hep.24742
DS Docta Complutense
RD 4 abr 2025