RT Journal Article
T1 The effect of smoking on clinical and structural damage in patients with axial spondyloarthritis: A systematic literature review
A1 Villaverde García, Virginia
A1 Cobo Ibáñez, Tatiana
A1 Candelas Rodríguez, Gloria Del Mar
A1 Seoane Mato, Daniel
A1 Díaz del Campo Fontecha, Petra
A1 Guerra, Mercedes
A1 Muñoz Fernández, Santiago
A1 Cañete, Juan D.
AB ObjectivesTo evaluate the association between smoking and clinical parameters and structural damage in axial spondyloarthritis (axSpA).MethodsWe systematically searched MEDLINE, EMBASE and Cochrane Library till November 2015. We selected articles that analysed the smoking impact on disease activity, functional status, structural damage, physical mobility and life quality. Independent extraction of articles by 2 authors using predefined data fields was performed. Studies quality was graded according to the Oxford Level of Evidence scale.ResultsA total of 17 articles were selected for inclusion: 2 case–control, 11 cross-sectional and 4 prospective cohort studies, which analysed 4694 patients. Weak evidence suggested a smoking effect on pain, overall assessment of health, disease activity, physical mobility and life quality in ankylosing spondylitis (AS). Moderate-good evidence revealed higher HAQ-AS among smokers (0.025 units/y; 95% CI: 0.0071–0.0429; p = 0.007). Every additional unit of ASDAS resulted in an increase of 1.9 vs. 0.4 mSASSS units/2 y in AS smokers vs. non-smokers. Good evidence revealed that cigarette smoking and smoking intensity was associated with spinal radiographic progression in axSpA [mSASSS ≥2 units/2 y: OR = 2.75, 95% CI: 1.25–6.05, p=0.012; mSASSS progression in heavy smokers (>10 cigarettes/d): OR = 3.57, 95% IC: 1.33–9.60, p = 0.012].ConclusionsPublished data indicate that smoking has a dose-dependent impact on structural damage progression in axSpA. There is worse HAQ among AS smokers compared to non-smokers. Respect to pain, overall assessment of health, disease activity, physical mobility and life quality, although the evidence level is poor, all evidence points in the same direction: smoking AS patients are worse than non-smoking.
PB Elsevier
SN 0049-0172
YR 2016
FD 2016-01-01
LK https://hdl.handle.net/20.500.14352/113862
UL https://hdl.handle.net/20.500.14352/113862
LA eng
NO Villaverde-García V, Cobo-Ibáñez T, Candelas-Rodríguez G, Seoane-Mato D, Campo-Fontecha PDD, Guerra M, Muñoz-Fernández S, Cañete JD. The effect of smoking on clinical and structural damage in patients with axial spondyloarthritis: A systematic literature review. Semin Arthritis Rheum. 2017 Apr;46(5):569-583. doi: 10.1016/j.semarthrit.2016.11.004
DS Docta Complutense
RD 17 dic 2025