RT Journal Article
T1 Greater Calcium Intake is Associated with Better Bone Health Measured by Quantitative Ultrasound of the Phalanges in Pediatric Patients Treated with Anticonvulsant Drugs
A1 Vera González, Vicente
A1 Moran, Jose
A1 Barros, Patricia
A1 Canal-Macias, Maria
A1 Guerrero-Bonmatty, Rafael
A1 Costa-Fernandez, Carmen
A1 Lavado-Garcia, Jesus
A1 Roncero-Martin, Raul
A1 Pedrera-Zamorano, Juan
AB We aimed to investigate and compare the effects of chronic antiepileptic therapy on bone health in pediatric patients using quantitative ultrasound of the phalanges (QUS) and controlling for potential confounding factors, particularly nutrient intake. The amplitude-dependent speed of sound (Ad-SoS) was measured in 33 epileptic children and 32 healthy children aged 6.5 ˘ 3.1 and 6.3 ˘ 1.1 (mean ˘ SD) years, respectively. There were no significant differences in the demographics such as age, weight and height between epileptic children and the control group children. None of the children in the epileptic or the treatment group were found to have a vitamin D deficiency. There were no significant differences in laboratory tests between groups. Lower QUS figures were found in the epileptic children (p = 0.001). After further adjustment for potential confounders such age, height, weight, calcium intake, vitamin D intake, physical activity and sex, the differences remained significant (p < 0.001). After further classification of the participants based on the tertile of calcium intake, no significant differences were found between patients and healthy controls in the greatest tertile of calcium intake (p = 0.217). We conclude that anticonvulsant therapy using valproate may lead to low bone mass in children and that an adequate intake of calcium might counteract such deleterious effects.
PB MDPI
SN 2072-6643
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/34245
UL https://hdl.handle.net/20.500.14352/34245
LA eng
DS Docta Complutense
RD 7 may 2024