RT Journal Article
T1 Animal Models of Cardiovascular Diseases
A1 Zaragoza, Carlos
A1 Gomez-Guerrero, Carmen
A1 Martin-Ventura, Jose Luis
A1 Blanco-Colio, Luis
A1 Lavín Plaza, Begoña
A1 Mallavia, Beñat
A1 Tarin, Carlos
A1 Mas, Sebastian
A1 Ortiz, Alberto
A1 Egido, Jesus
AB Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies. Several models have been developed to address cardiovascular complications, including atherothrombotic and cardiac diseases, and the same pathology have been successfully recreated in different species, including small and big animal models of disease. However, genetic and environmental factors play a significant role in cardiovascular pathophysiology, making difficult to match a particular disease, with a single experimental model. Therefore, no exclusive method perfectly recreates the human complication, and depending on the model, additional considerations of cost, infrastructure, and the requirement for specialized personnel, should also have in mind. Considering all these facts, and depending on the budgets available, models should be selected that best reproduce the disease being investigated. Here we will describe models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models of heart failure. Given the wide range of models available, today it is possible to devise the best strategy, which may help us to find more efficient and reliable solutions against human cardiovascular diseases.
PB Wiley
SN 1110-7243
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/96558
UL https://hdl.handle.net/20.500.14352/96558
LA eng
NO Zaragoza, Carlos, et al. «Animal Models of Cardiovascular Diseases». BioMed Research International, editado por Oreste Gualillo, vol. 2011, n.o 1, enero de 2011, p. 497841. DOI.org (Crossref), https://doi.org/10.1155/2011/497841.
NO Ministerio de Ciencia e Innovación (España)
NO Comunidad de Madrid
NO European Commission
DS Docta Complutense
RD 6 abr 2025