RT Journal Article
T1 Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy
A1 Ortega, Miguel A.
A1 Fraile Martínez, Oscar
A1 García Montero, Cielo
A1 Rodriguez Martín, Sonia
A1 Funes Moñux, Rosa M.
A1 Bravo Arribas, Coral
A1 De Leon Luis, Juan A.
A1 Saz, Jose V.
A1 Saez, Miguel A.
A1 Guijarro, Luis G.
A1 Lahera, Guillermo
A1 Monserrat Sanz, Jorge
A1 Mora Mínguez, Fernando
A1 Quintero Gutiérrez Del Álamo, Francisco Javier
A1 Bujan, Julia
A1 García Honduvilla, Natalio
A1 Álvarez Mon, Melchor
A1 Alvarez Mon, Miguel Ángel
AB Psychosis is a complex clinical syndrome resulting in a loss of contact with reality and alterations in behavior and sensorial and motor functions. Although the onset of psychosis can be related to any medical condition, most cases of psychosis are not fully understood. Psychosis may manifest for the first time during pregnancy, which is detrimental to maternofetal well-being. The impact of having a first episode of psychosis during pregnancy on the placenta has not yet been explored. Oxidative stress is thought to take part in the etiopathogenesis of this complex disorder, and this condition can also affect the placenta as it is highly sensitive to changes in the maternal environment. In this sense, the aim of the present work was to study the gene and protein expression through RT–qPCR and immunohistochemistry, respectively, of oxidative stress markers (NOX-1, NOX-2, iNOS, eNOS and PARP) in the placental tissue of women who underwent a first episode of psychosis during pregnancy (FE-PW) in comparison to healthy pregnant women. Our results showed augmented gene and protein expression of NOX-1, NOX-2, iNOS and PARP in the placental tissue of FE-PW. For the first time, we demonstrated that oxidative stress may have an important pathophysiological role in this tissue, aiding in explaining the impact of psychosis on pregnancy and the need for future studies in this field to guide better clinical management of these patients.
PB MDPI
SN 2076-3921
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/72344
UL https://hdl.handle.net/20.500.14352/72344
LA eng
NO This study (FIS-PI21/01244 and PI21/01252) was supported by the Instituto de Salud Carlos III (grant no. Estatal de I + D + I 2020–2027) and co-financed by the European Development Regional Fund “A way to achieve Europe” and P2022/BMD-7321 (Comunidad de Madrid), and Halekulani S.L. and MJR.
NO European Development Regional Fund “A way to achieve Europe”
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
NO Halekulani S.L.
NO MJR
DS Docta Complutense
RD 4 abr 2025