%0 Journal Article
%A Wicke, Pablo Delgado
%A Fernández de Córdoba Oñate, Sara
%A Roy Vallejo, Emilia
%A Alegría Carrasco, Estibaliz
%A Rodríguez Serrano, Diego A.
%A Lamana Domínguez, Amalia
%A Montes, Nuria
%A Nicolao Gómez, Ana
%A Carracedo Rodríguez, Rosa
%A Marcos Jiménez, Ana
%A Díaz Fernández, Paula
%A Galván Román, José M.
%A Rabes Rodríguez, Laura
%A Sanz Alba, Marta
%A Álvarez Rodríguez, Jesús
%A Villa Martí, Almudena
%A Rodríguez Franco, Carlos
%A Villapalos García, Gonzalo
%A Zubiaur, Pablo
%A Abad Santos, Francisco
%A De los Santos, Ignacio
%A Pérez Gomáriz, Rosa María
%A García Vicuña, Rosario
%A Muñoz Calleja, Cecilia
%A González Álvaro, Isidoro
%A Fernández Ruiz, Elena
%A Suárez Fernández, Carmen
%A Barrios, Ana
%A Sanz, Jesús
%A Casado, Pedro
%A Gutiérrez, Ángela
%A Bautista, Azucena
%A Hernández, Pilar
%A Ruiz Giménez, Nuria
%A Moyano, Berta
%A Gil, Paloma
%A Delgado, María Jesús
%A Parra, Pedro
%A Sánchez, Beatriz
%A Sáez, Carmen
%A Fernández Rico, Marta
%A Arévalo Román, Cristina
%A Ciudad, Marianela
%A Castañeda, Santos
%A Llorente, Irene
%A Tomero, Eva G.
%A García Castañeda, Noelia
%A Uriarte, Miren
%A Cardeñoso, Laura
%A Fontán García-Rodrigo, Leticia
%A Domingo García, Diego
%A Alarcón Cavero, Teresa
%A Semiglia Chong, María Auxiliadora
%A Gutiérrez Cobos, Ainhoa
%A Zurita Cruz, Nelly D.
%A Sánchez Madrid, Francisco
%A Martín Gayo, Enrique
%A Sánchez Cerrillo, Ildefonso
%A Martínez Fleta, Pedro
%A López Sanz, Celia
%A Gabrie, Ligia
%A Del Campo Guerola, Luciana
%A Tejedor, Reyes
%A Ancochea, Julio
%A García Castillo, Elena
%A Ávalos, Elena
%A Sánchez Azofra, Ana
%A Alonso, Tamara
%A Cisneros, Carolina
%A Valenzuela, Claudia
%A García Pérez, Francisco J.
%A Girón, Rosa M.
%A Aspa, Javier
%A Marcos, Celeste
%A Socorro Churruca, M. del Perpetuo
%A Zamora, Enrique
%A Martínez, Adrián
%A Barrio Mayo, Mar
%A Henares Espi, Rosalina
%A Méndez, Rosa
%A Arribas, David
%A Chicot Llano, Marta
%A González, Begoña
%A Quicios, Begoña
%A Patiño, Pablo
%A Trigueros, Marina
%A Dominguez Peña, Cristina
%A Jiménez Jiménez, David
%A Villamayor, Pablo
%A Canabal, Alfonso
%A De la Cámara, Rafael
%A Ortiz, Javier
%A Iturrate, Isabel
%T Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables
%D 2024
%U https://hdl.handle.net/20.500.14352/112192
%X The characteristics of the host are crucial in the final outcome of COVID-19. Herein, the influence of genetic and clinical variants in COVID-19 severity was investigated in a total of 1350 patients. Twenty-one single nucleotide polymorphisms of genes involved in SARS-CoV-2 sensing as Toll-like-Receptor 7, antiviral immunity as the type I interferon signalling pathway (TYK2, STAT1, STAT4, OAS1, SOCS) and the vasoactive intestinal peptide and its receptors (VIP/VIPR1,2) were studied. To analyse the association between polymorphisms and severity, a model adjusted by age, sex and different comorbidities was generated by ordinal logistic regression. The genotypes rs8108236-AA (OR 0.12 [95% CI 0.02–0.53]; p = 0.007) and rs280519-AG (OR 0.74 [95% CI 0.56–0.99]; p = 0.03) in TYK2, and rs688136-CC (OR 0.7 [95% CI 0.5–0.99]; p = 0.046) in VIP, were associated with lower severity; in contrast, rs3853839-GG in TLR7 (OR 1.44 [95% CI 1.07–1.94]; p = 0.016), rs280500-AG (OR 1.33 [95% CI 0.97–1.82]; p = 0.078) in TYK2 and rs1131454-AA in OAS1 (OR 1.29 [95% CI 0.95–1.75]; p = 0.110) were associated with higher severity. Therefore, these variants could influence the risk of severe COVID-19.
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