RT Journal Article
T1 Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables
A1 Wicke, Pablo Delgado
A1 Fernández de Córdoba Oñate, Sara
A1 Roy Vallejo, Emilia
A1 Alegría Carrasco, Estibaliz
A1 Rodríguez Serrano, Diego A.
A1 Lamana Domínguez, Amalia
A1 Montes, Nuria
A1 Nicolao Gómez, Ana
A1 Carracedo Rodríguez, Rosa
A1 Marcos Jiménez, Ana
A1 Díaz Fernández, Paula
A1 Galván Román, José M.
A1 Rabes Rodríguez, Laura
A1 Sanz Alba, Marta
A1 Álvarez Rodríguez, Jesús
A1 Villa Martí, Almudena
A1 Rodríguez Franco, Carlos
A1 Villapalos García, Gonzalo
A1 Zubiaur, Pablo
A1 Abad Santos, Francisco
A1 De los Santos, Ignacio
A1 Pérez Gomáriz, Rosa María
A1 García Vicuña, Rosario
A1 Muñoz Calleja, Cecilia
A1 González Álvaro, Isidoro
A1 Fernández Ruiz, Elena
A1 Suárez Fernández, Carmen
A1 Barrios, Ana
A1 Sanz, Jesús
A1 Casado, Pedro
A1 Gutiérrez, Ángela
A1 Bautista, Azucena
A1 Hernández, Pilar
A1 Ruiz Giménez, Nuria
A1 Moyano, Berta
A1 Gil, Paloma
A1 Delgado, María Jesús
A1 Parra, Pedro
A1 Sánchez, Beatriz
A1 Sáez, Carmen
A1 Fernández Rico, Marta
A1 Arévalo Román, Cristina
A1 Ciudad, Marianela
A1 Castañeda, Santos
A1 Llorente, Irene
A1 Tomero, Eva G.
A1 García Castañeda, Noelia
A1 Uriarte, Miren
A1 Cardeñoso, Laura
A1 Fontán García-Rodrigo, Leticia
A1 Domingo García, Diego
A1 Alarcón Cavero, Teresa
A1 Semiglia Chong, María Auxiliadora
A1 Gutiérrez Cobos, Ainhoa
A1 Zurita Cruz, Nelly D.
A1 Sánchez Madrid, Francisco
A1 Martín Gayo, Enrique
A1 Sánchez Cerrillo, Ildefonso
A1 Martínez Fleta, Pedro
A1 López Sanz, Celia
A1 Gabrie, Ligia
A1 Del Campo Guerola, Luciana
A1 Tejedor, Reyes
A1 Ancochea, Julio
A1 García Castillo, Elena
A1 Ávalos, Elena
A1 Sánchez Azofra, Ana
A1 Alonso, Tamara
A1 Cisneros, Carolina
A1 Valenzuela, Claudia
A1 García Pérez, Francisco J.
A1 Girón, Rosa M.
A1 Aspa, Javier
A1 Marcos, Celeste
A1 Socorro Churruca, M. del Perpetuo
A1 Zamora, Enrique
A1 Martínez, Adrián
A1 Barrio Mayo, Mar
A1 Henares Espi, Rosalina
A1 Méndez, Rosa
A1 Arribas, David
A1 Chicot Llano, Marta
A1 González, Begoña
A1 Quicios, Begoña
A1 Patiño, Pablo
A1 Trigueros, Marina
A1 Dominguez Peña, Cristina
A1 Jiménez Jiménez, David
A1 Villamayor, Pablo
A1 Canabal, Alfonso
A1 De la Cámara, Rafael
A1 Ortiz, Javier
A1 Iturrate, Isabel
AB The characteristics of the host are crucial in the final outcome of COVID-19. Herein, the influence of genetic and clinical variants in COVID-19 severity was investigated in a total of 1350 patients. Twenty-one single nucleotide polymorphisms of genes involved in SARS-CoV-2 sensing as Toll-like-Receptor 7, antiviral immunity as the type I interferon signalling pathway (TYK2, STAT1, STAT4, OAS1, SOCS) and the vasoactive intestinal peptide and its receptors (VIP/VIPR1,2) were studied. To analyse the association between polymorphisms and severity, a model adjusted by age, sex and different comorbidities was generated by ordinal logistic regression. The genotypes rs8108236-AA (OR 0.12 [95% CI 0.02–0.53]; p = 0.007) and rs280519-AG (OR 0.74 [95% CI 0.56–0.99]; p = 0.03) in TYK2, and rs688136-CC (OR 0.7 [95% CI 0.5–0.99]; p = 0.046) in VIP, were associated with lower severity; in contrast, rs3853839-GG in TLR7 (OR 1.44 [95% CI 1.07–1.94]; p = 0.016), rs280500-AG (OR 1.33 [95% CI 0.97–1.82]; p = 0.078) in TYK2 and rs1131454-AA in OAS1 (OR 1.29 [95% CI 0.95–1.75]; p = 0.110) were associated with higher severity. Therefore, these variants could influence the risk of severe COVID-19.
PB Nature Research
YR 2024
FD 2024-09
LK https://hdl.handle.net/20.500.14352/112192
UL https://hdl.handle.net/20.500.14352/112192
LA eng
NO Delgado-Wicke, P., Fernández de Córdoba-Oñate, S., Roy-Vallejo, E. et al. Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables. Sci Rep 14, 20728 (2024). https://doi.org/10.1038/s41598-024-71476-2
NO Funding:This study was funded with grants: “Fondos Supera COVID19” by Banco Santander and CRUE to CM-C and RPG; RD21/0002/0027, PI18/0371 and PI21/00526 to IG-Á; PI19/00096 and PI22/00428 to EF-R and RICORS RD21/0002/0004 to RPG from Ministerio de Ciencia e Innovación (Instituto de Salud Carlos III, ISCIII), co-funded by European Regional Development Fund (ERDF) “A way to make Europe”; and co-financed by the Community of Madrid (CAM) through the COVID 2019 Aid to IdeS. The work of ER-V and AM-J was funded by Rio-Hortega grants CM19/00149 and CM19/00254, respectively, from the Ministerio de Ciencia e Innovación (Instituto de Salud Carlos III, ISCIII) and co-funded by The ERDF "A way to make Europe"; GV-G and PD-F were co-financed by ISCIII and the European Social Fund (PFIS grants FI20/00090 and FI19/00092, respectively). PZ was financed by Universidad Autónoma de Madrid, Margarita Salas contract, grants for the requalification of the Spanish university system. EA-C and AN-G were financed by INVESTIGO (2022-C23.I01.P03.S0020-0000031) and INVESTIGO CAM (09-PIN1-00015.6/2022), by Ministerio de Ciencia e Innovación and CAM respectively, both financed by the European Union's Recovery, Transformation and Resilience Plan and NextGenerationEU.
NO European Commission
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos III
NO Comunidad de Madrid
NO CRUE Universidades Españolas
NO Universidad Autónoma de Madrid
NO Banco Santander
DS Docta Complutense
RD 10 abr 2025