RT Journal Article
T1 Sex-related disparities in the incidence and outcomes of infective endocarditis according to type 2 diabetes mellitus status in Spain, 2016–2020
A1 López De Andrés, Ana Isabel
A1 Jiménez García, Rodrigo
A1 Hernández Barrera, Valentín
A1 Miguel Díez, Javier De
A1 Miguel Yanes, José María De
A1 Martínez Hernández, David
A1 Carabantes Alarcón, David
A1 Zamorano León, José Javier
A1 Noriega, Concepción
AB Background: We performed a study to assess sex-differences in incidence (2016-2020), clinical characteristics, use of therapeutic procedures, and in-hospital outcomes in patients with infective endocarditis (IE) according to T2DM status.Methods: Ours was a retrospective cohort study using data from the Spanish National Hospital Discharge Database. We estimated the incidence of hospitalizations for IE in men and women aged ≥ 40 years with and without T2DM. Propensity score matching (PSM) and multivariable logistic regression were used to compare subgroups according to sex and the presence of T2DM.Results: From 2016 to 2020, IE was coded in 9,958 patients (66.79% men). T2DM was diagnosed in 2,668 (26.79%). The incidence of IE increased significantly from 15.29 cases per 100,000 persons with T2DM in 2016 to 17.69 in 2020 (p < 0.001). However, this increment was significant only among men with T2DM (19.47 cases per 100,000 in 2016 vs. 22.84 in 2020; p = 0.003). The age-adjusted incidence of IE was significantly higher in people with T2DM (both sexes) than in those without T2DM (IRR, 2.86; 95% CI, 2.74-2.99). The incidence of IE was higher in men with T2DM than in women with T2DM (adjusted IRR, 1.85; 95% CI, 1.54-3.31). After PSM, in-hospital mortality (IHM) was higher among T2DM women than matched T2DM men (22.65% vs. 18.0%; p = 0.018). The presence of T2DM was not associated with IHM in men or women.Conclusions: T2DM is associated with a higher incidence of hospitalization for IE. Findings for T2DM patients who had experienced IE differed by sex, with higher incidence rates and lower IHM in men than in women. T2DM was not associated to IHM in IE in men or in women.
PB BMC
SN 1475-2840
YR 2022
FD 2022-09-30
LK https://hdl.handle.net/20.500.14352/108850
UL https://hdl.handle.net/20.500.14352/108850
LA eng
NO Lopez-de-Andres A, Jimenez-Garcia R, Hernández-Barrera V, de-Miguel-Díez J, de-Miguel-Yanes JM, Martinez-Hernandez D, Carabantes-Alarcon D, Zamorano-Leon JJ, Noriega C. Sex-related disparities in the incidence and outcomes of infective endocarditis according to type 2 diabetes mellitus status in Spain, 2016-2020. Cardiovasc Diabetol. 2022 Sep 30;21(1):198. doi: 10.1186/s12933-022-01633-2.
NO Fondos FEDERConvenio V-PRICIT de la Comunidad de Madrid y la Universidad Complutense de Madrid (“Programa de Excelencia para el Profesorado Universitario” INV.AY.20.2021.1E126).
NO European Commission
NO Instituto de Salud Carlos III (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 19 abr 2025