RT Journal Article
T1 BODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosis
A1 Tabero, Andrea
A1 García-Garrido, Fernando
A1 Prieto Castañeda, Alejandro
A1 Palao, Eduardo
A1 Rodríguez Agarrabeitia, Antonia
A1 García-Moreno, Inmaculada
A1 Villanueva Valdés, Miguel Ángel
A1 Moya Cerero, Santiago De La
A1 Ortiz, María José
AB Endowing BODIPY PDT agents with the ability to probe lipid droplets is demonstrated to boost their phototoxicity, allowing the efficient use of highly fluorescent dyes (poor ROS sensitizers) as phototoxic agents. Conversely, this fact opens the way to the development of highly bright ROS photosensitizers for performing photodynamic theragnosis (fluorescence bioimaging and photodynamic therapy) from a single simple agent. On the other hand, the noticeable capability of some of the reported dyes to probe lipid droplets in different cell lines under different conditions reveals their use as privileged probes for advancing the study of interesting lipid droplets by fluorescence microscopy.
PB Royal Society of Chemistry
YR 2019
FD 2019-12-11
LK https://hdl.handle.net/20.500.14352/91823
UL https://hdl.handle.net/20.500.14352/91823
LA eng
NO Tabero, A.; García-Garrido, F.; Prieto-Castañeda, A.; Palao, E.; Agarrabeitia, A. R.; García-Moreno, I.; Villanueva, A.; De la Moya, S., Chem. Commun., 2020, 56, 940-943
DS Docta Complutense
RD 1 sept 2024