RT Journal Article
T1 An Abscopal Effect on Lung Metastases in Canine Mammary Cancer Patients Induced by Neoadjuvant Intratumoral Immunotherapy with Cowpea Mosaic Virus Nanoparticles and Anti-Canine PD-1
A1 Sergent, Petra
A1 Pinto-Cárdenas, Juan Carlos
A1 Arreguin Carrillo, Adhara Jaciel
A1 Luna Dávalos, Daniel
A1 González Pérez, Marisa Daniela
A1 Mendoza Lechuga, Dora Alicia
A1 Alonso Miguel, Daniel
A1 Schaafsma, Evelien
A1 Jiménez Cuarenta, Abigail
A1 Cárdenas Muñoz, Diana
A1 Zarabanda, Yuliana
A1 Palisoul, Scott M.
A1 Lewis, Petra J.
A1 Kolling IV, Fred W.
A1 Affonso de Oliveira, Jessica Fernanda
A1 Steinmetz, Nicole F.
A1 Rothstein, Jay L.
A1 Lines, Louise
A1 Noelle, Randolph J.
A1 Fiering, Steven
A1 Arias Pulido, Hugo
AB Neoadjuvant intratumoral (IT) therapy could amplify the weak responses to checkpoint blockade therapy observed in breast cancer (BC). In this study, we administered neoadjuvant IT anti-canine PD-1 therapy (IT acPD-1) alone or combined with IT cowpea mosaic virus therapy (IT CPMV/acPD-1) to companion dogs diagnosed with canine mammary cancer (CMC), a spontaneous tumor resembling human BC. CMC patients treated weekly with acPD-1 (n = 3) or CPMV/acPD-1 (n = 3) for four weeks or with CPMV/acPD-1 (n = 3 patients not candidates for surgery) for up to 11 weeks did not experience immune-related adverse events. We found that acPD-1 and CPMV/acPD-1 injections resulted in tumor control and a reduction in injected tumors in all patients and in noninjected tumors located in the ipsilateral and contralateral mammary chains of treated dogs. In two metastatic CMC patients, CPMV/acPD-1 treatments resulted in the control and reduction of established lung metastases. CPMV/acPD-1 treatments were associated with altered gene expression related to TLR1-4 signaling and complement pathways. These novel therapies could be effective for CMC patients. Owing to the extensive similarities between CMC and human BC, IT CPMV combined with approved anti-PD-1 therapies could be a novel and effective immunotherapy to treat local BC and suppress metastatic BC.
PB MDPI
YR 2024
FD 2024-09-03
LK https://hdl.handle.net/20.500.14352/108215
UL https://hdl.handle.net/20.500.14352/108215
LA eng
NO Sergent, P., Pinto-Cárdenas, J. C., Carrillo, A. J. A., Dávalos, D. L., Pérez, M. D. G., Lechuga, D. A. M., Alonso-Miguel, D., Schaafsma, E., Cuarenta, A. J., Muñoz, D. C., Zarabanda, Y., Palisoul, S. M., Lewis, P. J., Kolling, F. W., 4th, Affonso de Oliveira, J. F., Steinmetz, N. F., Rothstein, J. L., Lines, L., Noelle, R. J., Fiering, S., … Arias-Pulido, H. (2024). An Abscopal Effect on Lung Metastases in Canine Mammary Cancer Patients Induced by Neoadjuvant Intratumoral Immunotherapy with Cowpea Mosaic Virus Nanoparticles and Anti-Canine PD-1. Cells, 13(17), 1478. https://doi.org/10.3390/cells13171478
NO National Cancer Institute (NCI)
NO Center for Clinical Genomics and Advanced Technology, Pathology Shared Resource
NO National Institutes of Health (NIH)
DS Docta Complutense
RD 11 abr 2025