RT Journal Article
T1 Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
A1 Sánchez Salcedo, Sandra
A1 Malavasi, Gianluca
A1 Salinas Sánchez, Antonio J.
A1 Lusvardi, Gigliola
A1 Rigamonti, Luca
A1 Menabue, Ledi
A1 Vallet Regí, María Dulce Nombre
AB Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO2–yCaO–zP2O5–5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2–15CaO–5P2O5 MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications.
PB MDPI
SN 1996-1944
YR 2018
FD 2018-03-02
LK https://hdl.handle.net/20.500.14352/12709
UL https://hdl.handle.net/20.500.14352/12709
LA eng
NO Unión Europea. Horizonte 2020
NO Ministerio de Economía y Competitividad (MINECO)
NO Instituto de Salud Carlos III (ISCIII)
NO University of Modena and Reggio Emilia “Progetto Mobilità Internazionale”
DS Docta Complutense
RD 30 abr 2024