RT Journal Article
T1 The tale of microencapsulated rifampicin: is it useful for the treatment of periprosthetic joint infection?
A1 López Torres, Irene Isabel
A1 Vaquero Martín, Francisco Javier
A1 Torres Suárez, Ana Isabel
A1 Navarro García, Federico
A1 Fraguas Sánchez, Ana Isabel
A1 León Román, Víctor Estuardo
A1 Sanz Ruiz, Pablo
AB PurposeMicroencapsulation techniques have allowed the addition of rifampicin to bone cement, but its in vivo efficacy has not been proven. The aim of our study is to determine the superiority of cement containing gentamicin and rifampicin microcapsules in the treatment of PJI versus cement exclusively containing gentamicin.MethodsAn S. aureus PJI was induced in 15 NZW rabbits. A week after inoculation, the first stage of replacement was carried out, and the animals were divided into two groups: group R received a spacer containing gentamicin and rifampicin microcapsules, and group C received a spacer containing gentamicin. Intra-articular release curve of rifampicin and infection and toxicity markers were monitored for four weeks post-operatively, when microbiological analysis was performed.ResultsThe microbiological cultures showed a significantly lower growth of S. aureus in soft tissue (2.3·104 vs 0; p = 0.01) and bone (5.7·102 vs 0; p = 0.03) in the group with rifampicin microcapsules. No differences were found in systemic toxicity markers. Rifampicin release from the cement spacer showed higher concentrations than the staphylococcal MIC throughout the analysis.ConclusionThe in vivo analyses demonstrated the superiority of cement containing gentamicin and rifampicin microcapsules versus the isolated use of gentamicin in the treatment of PJI in the rabbit model without serious side effects due to the systemic absorption of rifampicin. Given the increasing incidence of staphylococci-related PJI, the development of new strategies for intra-articular administration of rifampicin for its treatment has a high clinical impact.
PB Springer
SN 0341-2695
YR 2022
FD 2022-01-06
LK https://hdl.handle.net/20.500.14352/71323
UL https://hdl.handle.net/20.500.14352/71323
LA eng
NO López Torres, I. I., Vaquero Martín, F. J., Torres Suárez, A. I. et al. «The Tale of Microencapsulated Rifampicin: Is It Useful for the Treatment of Periprosthetic Joint Infection?» International Orthopaedics, vol. 46, n.o 4, abril de 2022, pp. 677-85. DOI.org (Crossref), https://doi.org/10.1007/s00264-021-05290-0.
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Universidad Complutense de Madrid/Banco de Santander
NO Mutual Medica scholarships (2017)
DS Docta Complutense
RD 16 abr 2025