RT Journal Article
T1 Differential patterns of functional connectivity in Progressive and Stable Mild Cognitive Impairment subjects
A1 Bajo Bretón, Ricardo
A1 Castellanos, Nazareth P.
A1 Cuesta Prieto, Pablo
A1 Aurtenetxe, Sara
A1 Gil Gregorio, Pedro
A1 Pozo, Francisco del
A1 Maestu Unturbe, Fernando
AB It is now widely accepted that Alzheimer's disease is characterized by a functional disconnection between brain regions. The disease appears to begin up to decades prior to clinical diagnosis. Therefore, in the present study, we combined magnetoencephalography, a memory task, and functional connectivity analysis in mild cognitive impairment subjects in order to identify functional connectivity patterns that could characterize subjects who would eventually go on to develop the disease. We monitored 19 subjects and finally 5 of them developed Alzheimer's disease. These progressive patients showed a differential profile of functional connectivity values compared with those patients who remained stable over time. Specifically there were higher synchronization values over the parieto-occipital region in α and β frequency bands. The involvement of this brain region in amyloid-β accumulation and its possible association with hyper-synchronization are also discussed.
PB Mary Ann Liebert, Inc.
SN 2158-0014
YR 2012
FD 2012-05-10
LK https://hdl.handle.net/20.500.14352/101018
UL https://hdl.handle.net/20.500.14352/101018
LA eng
NO Ricardo Bajo, Nazareth P. Castellanos, Pablo Cuesta, Sara Aurtenetxe, Juan Garcia-Prieto, Pedro Gil-Gregorio, Francisco del-Pozo, and Fernando Maestu. Differential Patterns of Connectivity in Progressive Mild Cognitive Impairment. Brain Connectivity.Feb 2012.21-24.
DS Docta Complutense
RD 18 jul 2024