RT Journal Article
T1 Silicon‐Enriched Restructured Meat Mitigates Metabolic Dysfunction‐Associated Steatohepatitis in a Late‐Stage Type 2 Diabetes Mellitus Rat Model
A1 Redondo‐Castillejo, Rocío
A1 Hernández Martín, Marina
A1 Bocanegra De Juana, Aranzazu
A1 Macho González, Adrián
A1 García Fernández, Rosa Ana
A1 Apaza Ticona, Luis Nestor
A1 Bastida Codina, Sara
A1 Sánchez Muniz, Francisco José
A1 López-Oliva Muñoz, María Elvira
A1 Garcimartín Álvarez, Alba
A1 Benedí González, Juana María
AB Functional foods with antidiabetic and lipid-lowering properties may serve as a nutritional strategy for metabolic dysfunction-associated steatohepatitis (MASH), especially when coexisting with type 2 diabetes mellitus (T2DM). This study evaluates whether the consumption of silicon-enriched restructured meat (Si-RM) could alleviate hepatic injury and metabolic disturbances in a late-stage T2DM rat model. Early-stage (ED, n = 8) and late-stage (LD, n = 16) T2DM were induced following a high-saturated-fat diet or a high-saturated-fat, high-cholesterol diet plus streptozotocin/nicotinamide injection, respectively, both diets containing a control meat. After confirming hyperglycemia, half of LD rats received Si-RM for 5 weeks (LD-Si, n = 8). Metabolic indices, liver histology, oxysterols, hepatic ChREBP/SREBP-1c, proliferation/apoptosis balance, and antioxidant defenses were assessed. LD rats developed clear histopathological and biochemical MASH. Si-RM consumption partially ameliorated these alterations, showing reduced lobular inflammation, improved serum oxysterol profile (decreased 25- and 27-hydroxycholesterols, increased 7-hydroxylated cholesterols), downregulated hepatic ChREBP, restored SREBP-1c, rebalanced proliferation to apoptosis ratio, and enhanced antioxidant defenses. Si-RM mitigated MASH severity and improved hepatic oxidative and metabolic status in a late-stage T2DM. These findings support the therapeutic potential of Si-RM as a promising and accessible nutritional adjuvant strategy against MASH
PB Wiley
SN 1613-4125
YR 2026
FD 2026
LK https://hdl.handle.net/20.500.14352/132855
UL https://hdl.handle.net/20.500.14352/132855
LA eng
NO Redondo‐Castillejo R, Hernández‐Martín M, Bocanegra A, et al. Silicon‐Enriched Restructured Meat Mitigates Metabolic Dysfunction‐Associated Steatohepatitis in a Late‐Stage Type 2 Diabetes Mellitus Rat Model. Molecular Nutrition Food Res 2026;70:e70404. https://doi.org/10.1002/mnfr.70404
NO Comunidad de Madrid
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 8 abr 2026