RT Journal Article
T1 Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index
A1 Tesolato, Sofía
A1 González-Gamo, Daniel
A1 Barabash Bustelo, Ana
A1 Claver, Paula
A1 De La-Serna Esteban, Sofía Cristina
A1 Domínguez Serrano, María Inmaculada
A1 Dziakova, Jana
A1 Juan Chocano, María Del Carmen De
A1 Torres García, Antonio José
A1 Iniesta Serrano, María Pilar
A2 Sterpetti, Antonio V.
AB Colorectal cancer (CRC) is one of the main tumor pathologies in our societyconsidering its incidence and mortality. Various authors have linked the development of CRC with overweight and obesity. However, no molecular markers have been defined to connect both pathologies and that can be assessed in serum for diagnostic and/or prognostic purposes. The main objective of this work is to analyze and correlate the expression levels of four miRNAs previously associated with cancer and/or obesity in patients affected by CRC, as well as in a control group without cancer, considering the body mass index (BMI) of subjects. The main novelty of this study consists in the variety of samples investigated: adipose tissues, omental and subcutaneous; serum; and tumor and non-tumor tissues in the case of CRC patients. Results  conclude about the utility mainly of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
PB MDPI
SN 2072-6694
YR 2023
FD 2023-06-24
LK https://hdl.handle.net/20.500.14352/91602
UL https://hdl.handle.net/20.500.14352/91602
LA eng
NO Tesolato, S.E.; González-Gamo, D.; Barabash, A.; Claver, P.; de la Serna, S.C.; Domínguez-Serrano, I.; Dziakova, J.; de Juan, C.; Torres, A.J.; Iniesta, P. Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the BodyMass Index. Cancers 2023, 15, 3324. https://doi.org/10.3390/ cancers15133324
NO Carlos III Institute of Health (Ministerio de Economía y Competitividad), Spain
NO European Union through the European Regional Development Fund (ERDF) ‘A way to make Europe’
DS Docta Complutense
RD 30 sept 2024