RT Journal Article
T1 Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
A1 Cazorla Luna, Raúl
A1 Notario Pérez, Fernando
A1 Martín Illana, Araceli
A1 Ruiz Caro, Roberto
A1 Tamayo, Aitana
A1 Rubio, Juan
A1 Veiga Ochoa, María Dolores
AB Vaginal microbicides have the potential to give women at high risk of contracting HIV the option of self-protection by preventing the sexual transmission of the virus. In this paper, mucoadhesive vaginal tablets based on chitosan, alone and in combination with pectin and locust bean gum, were developed for the sustained release of tenofovir (an antiretroviral drug). The formulations were placed in simulant vaginal fluid (SVF) to swell, and Hg porosity and SEM microscopy were used for the microstructural characterization of the swelling witnesses. The results show that the association of pectin and chitosan generated polyelectrolyte complexes and produced a robust system able to maintain its structure during the swelling process, when small pores are formed. Drug reléase and bovine vaginal mucoadhesion studies were performed in SVF showing that tenofovir-controlled dissolution profiles and adhesion to the mucosa were conditioned by the swelling processes of the polymer/s in each formulation. Tablets based on chitosan/pectin have the most homogeneous tenofovir dissolution profiles and last up to 96 h, remaining attached to the vaginal mucosa for the same period. These formulations can therefore be considered a good option for the self-protection of women from the sexual transmission of HIV.
PB MDPI
SN 1999-4923
YR 2019
FD 2019-01-05
LK https://hdl.handle.net/20.500.14352/12758
UL https://hdl.handle.net/20.500.14352/12758
LA eng
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
NO Spanish Research Agency and the European Regional Development Fund (AEI/FEDER, UE)
DS Docta Complutense
RD 18 jul 2024