%0 Journal Article
%A González Gálvez, Beatriz
%A León Sanz, Miguel Francisco José
%A Saco-Ledo, Gonzalo
%A Valenzuela, Pedro L.
%A Almazan-Polo, Jaime
%A Plaza-Florido, Abel
%A Alejo, Lidia B.
%A Bustos, Asunción
%A Río-García, Antía
%A Rubio-Gonzalez, Esther
%A Fiuza-Luces, Carmen
%A Boraita, Araceli
%A Santos-Lozano, Alejandro
%A Lucia, Alejandro
%A Ruilope Urioste, Luis Miguel
%T Acute physical exercise and ambulatory blood pressure in resistant hypertension
%D 2025
%U https://hdl.handle.net/20.500.14352/121246
%X OBJECTIVES: The effects of acute physical exercise in patients with resistant  hypertension remain largely unexplored compared with hypertensive patients in  general. We assessed the short-term effects of acute moderate-intensity (MICE)  and high-intensity interval exercise (HIIE) on the clinic (BP) and 24-h  ambulatory blood pressure (ABP) of patients with resistant hypertension. METHODS: Using a crossover randomized controlled design, 10 participants  (56 ± 7 years) with resistant hypertension performed three experimental  sessions: MICE, HIIE, and control. MICE consisted of continuous treadmill  exercise at an intensity of 3-4 metabolic equivalents of energy (METs) until  completing 3 kcal/kg and was energy-matched to HIIE (which included six to eight  intervals of 3 min duration at 6-7 METs interspersed with 1.5-min rests at 3  METs). In the control session, participants remained seated for 50 min.  Flow-mediated vasodilation, autonomic nervous system balance (heart rate  variability), exerkines [interleukin (IL)-6, IL-8, IL-15, vascular endothelial  growth factor A, irisin, adiponectin, and angiopoietin] and 71  inflammatory-related proteins were also measured. RESULTS: Compared with baseline, HIIE and MICE reduced clinic SBP immediately (  P  < 0.001 for both) and 90 min ( P  = 0.001 and P  = 0.041, respectively)  postexercise. HIIE and MICE also reduced clinic DBP immediately postexercise ( P   = 0.003 and P  = 0.025). By contrast, no changes were found in the control  session. On the other hand, no significant effects were noted for 24 h ABP  measures or for the rest of variables. CONCLUSION: Although in patients with resistant hypertension, acute aerobic  exercise induces short-term reductions in clinic BP, this stimulus does not  suffice to reduce 24 h ABP or to impact on potential biological mechanisms.
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