RT Journal Article
T1 Acute physical exercise and ambulatory blood pressure in resistant hypertension
A1 González Gálvez, Beatriz
A1 León Sanz, Miguel Francisco José
A1 Saco-Ledo, Gonzalo
A1 Valenzuela, Pedro L.
A1 Almazan-Polo, Jaime
A1 Plaza-Florido, Abel
A1 Alejo, Lidia B.
A1 Bustos, Asunción
A1 Río-García, Antía
A1 Rubio-Gonzalez, Esther
A1 Fiuza-Luces, Carmen
A1 Boraita, Araceli
A1 Santos-Lozano, Alejandro
A1 Lucia, Alejandro
A1 Ruilope Urioste, Luis Miguel
AB OBJECTIVES: The effects of acute physical exercise in patients with resistant  hypertension remain largely unexplored compared with hypertensive patients in  general. We assessed the short-term effects of acute moderate-intensity (MICE)  and high-intensity interval exercise (HIIE) on the clinic (BP) and 24-h  ambulatory blood pressure (ABP) of patients with resistant hypertension. METHODS: Using a crossover randomized controlled design, 10 participants  (56 ± 7 years) with resistant hypertension performed three experimental  sessions: MICE, HIIE, and control. MICE consisted of continuous treadmill  exercise at an intensity of 3-4 metabolic equivalents of energy (METs) until  completing 3 kcal/kg and was energy-matched to HIIE (which included six to eight  intervals of 3 min duration at 6-7 METs interspersed with 1.5-min rests at 3  METs). In the control session, participants remained seated for 50 min.  Flow-mediated vasodilation, autonomic nervous system balance (heart rate  variability), exerkines [interleukin (IL)-6, IL-8, IL-15, vascular endothelial  growth factor A, irisin, adiponectin, and angiopoietin] and 71  inflammatory-related proteins were also measured. RESULTS: Compared with baseline, HIIE and MICE reduced clinic SBP immediately (  P  < 0.001 for both) and 90 min ( P  = 0.001 and P  = 0.041, respectively)  postexercise. HIIE and MICE also reduced clinic DBP immediately postexercise ( P   = 0.003 and P  = 0.025). By contrast, no changes were found in the control  session. On the other hand, no significant effects were noted for 24 h ABP  measures or for the rest of variables. CONCLUSION: Although in patients with resistant hypertension, acute aerobic  exercise induces short-term reductions in clinic BP, this stimulus does not  suffice to reduce 24 h ABP or to impact on potential biological mechanisms.
PB Wolters Kluwer Health
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/121246
UL https://hdl.handle.net/20.500.14352/121246
LA eng
NO Saco-Ledo G, Valenzuela PL, Almazán-Polo J, Plaza-Florido A, Alejo LB, Bustos A, et al. Acute physical exercise and ambulatory blood pressure in resistant hypertension. Journal of Hypertension 2025;43:445–55. https://doi.org/10.1097/HJH.0000000000003924.
NO Funding: research by L.R., M.L.S., L.B.A., and G.S.L is funded by FEDER/Ministerio de Ciencia e Innovacion – Agencia Estatal de Investigacion, Spain (PID2020- 114862RB-I00/AEI/10.13039/501100011033). P.L.V. is supported by a Sara Borrell postdoctoral contract by Instituto de Salud Carlos III (CD21/00138). A.P.F. is supported in part by PERC Systems Biology Fund.
NO Agencia Estatal de Investigación (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 24 abr 2026