RT Journal Article
T1 Diadenosine polyphosphates in the tears of aniridia patients
T2 Diadenosina polifosfatos en la lágrima de pacientes con aniridia
A1 Peral Cerda, María Asunción
A1 Carracedo Rodríguez, Juan Gonzalo
A1 Pintor Just, Jesús Jerónimo
AB Purpose: To quantify diadenosine polyphosphate levels in tears of congenital aniridia patients to estimate the ocular surface changes associated with congenital aniridia compared to normal individuals.Methods: Fifteen patients diagnosed with congenital aniridia and a control group of forty volunteers were studied. Tears were collected to quantify the levels of diadenosine polyphosphates Ap4A and Ap5A by high-performance liquid chromatography (H.P.L.C). Break-up time (BUT), corneal staining, McMon- nies questionnaire and the Schirmer I test were applied to both groups. Results: Dinucleotides in congenital aniridia patients were higher than in control subjects. For the congenital aniridia group, under 15 years old, the values were 0.77   0.01 lM and 0.17   0.02 lM for Ap4A and Ap5A, respectively. The group aged from 15 to 40 years old provided concentrations of 4.37   0.97 lM and 0.46   0.05 lM for Ap4A and Ap5A, the group over 40 gave concentrations of 11.17   5.53 lM and 0.68   0.17 lM for Ap4A and Ap5A. Dinucleotide concentrations increased with age, being statistically significant different among the three age groups (p < 0.05). Congenital aniridia patients showed a normal tear secretion and no dry eye McMonnies scores, except for the group over 40 years old. BUT values decreased and corneal staining increased with age and correlated with the levels of diadenosine polyphosphates (p < 0.05). Conclusions: The levels of dinucleotides in tears increase in aniridia patients compared with healthy subjects, and they seem to be related with the progression of corneal disorders in aniridia patients, both of which increase with ageing.
PB Wiley
SN 1755-375X
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/92890
UL https://hdl.handle.net/20.500.14352/92890
LA eng
NO Peral, Assumpta, et al. «Diadenosine Polyphosphates in the Tears of Aniridia Patients». Acta Ophthalmologica, vol. 93, n.o 5, agosto de 2015. DOI.org (Crossref), https://doi.org/10.1111/aos.12626.
NO Redes temáticas de Investigación Cooperativa en Salud (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 12 abr 2025