RT Journal Article
T1 Allergenicity of vertebrate tropomyosins: Challenging an immunological dogma
A1 Daschner, A.
A1 González Fernández, Juan
A1 Cuéllar Del Hoyo, María Del Carmen
AB With the exception of tilapia tropomyosin, other anecdotic reports of tropomyosin recognition of vertebrate origin are generally not accompanied by clinical significance and a dogmatic idea is generally accepted about the inexistence of allergenicity of vertebrate tropomyosins, based mainly on sequence similarity evaluations with human tropomyosins. Recently, a specific work-up of a tropomyosin sensitised patient with seafood allergy, demonstrated that the IgE-recognition of tropomyosin from different fish species can be clinically relevant. We hypothesise that some vertebrate tropomyosins could be relevant allergens. The hypothesis is based on the molecular evolution of the proteins and it was tested by in silico methods. Fish, which are primitive vertebrates, could have tropomyosins similar to those of invertebrates. If the hypothesis is confirmed, tropomyosin should be included in different allergy diagnosis tools to improve the medical protocols and management of patients with digestive or cutaneous symptoms after fish intake.
PB Elsevier
SN 0301-0546
YR 2017
FD 2017-05
LK https://hdl.handle.net/20.500.14352/94044
UL https://hdl.handle.net/20.500.14352/94044
LA eng
NO González-Fernández J, Daschner A, Cuéllar C. Allergenicity of vertebrate tropomyosins: Challenging an immunological dogma. Allergol Immunopathol (Madr). 2017 May-Jun;45(3):297-304.
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 4 ago 2024