RT Journal Article
T1 Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal
A1 Acero, Nuria
A1 Ortega Hernández-Agero, María Teresa
A1 Villagrasa, Victoria
A1 León, Gemma
A1 Muñoz Mingarro, Dolores
A1 Castillo, Encarna
A1 González-Rosende, María Victoria
A1 Borrás, Silvia
A1 Ríos, Jose Luis
A1 Bosch-Morell, Francisco
A1 Martínez-Solis, Isabel
AB The incidence and prevalence of age-related neurodegenerative dementias have been increasing. There is no curative therapy and conventional drug treatment can cause problems for patients. Medicinal plants traditionally used for problems associated with ageing are emerging as a therapeutic resource. The main aim is to give a proposal for use and future research based on scientific knowledge and tradition. A literature search was conducted in several searchable databases. The keywords used were related to neurodegenerative dementias, ageing and medicinal plants. Boolean operators and filters were used to focus the search. As a result, there is current clinical and preclinical scientific information on 49 species used in traditional medicine for ageing-related problems, including neurodegenerative dementias. There are preclinical and clinical scientific evidences on their properties against protein aggregates in the central nervous system and their effects on neuroinflammation, apoptosis dysregulation, mitochondrial dysfunction, gabaergic, glutamatergic and dopaminergic systems alterations, monoamine oxidase alterations, serotonin depletion and oestrogenic protection. In conclusion, the potential therapeutic effect of the different medicinal plants depends on the type of neurodegenerative dementia and its stage of development, but more clinical and preclinical research is needed to find better, safer and more effective treatments.
PB Wiley Online Library
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/99143
UL https://hdl.handle.net/20.500.14352/99143
LA eng
NO Acero N, Ortega T, Villagrasa V, Leon G, Muñoz-Mingarro D, Castillo E, González-Rosende ME, Borrás S, Rios JL, Bosch-Morell F, Martínez-Solís I. Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal. Phytother Res. 2023 Mar;37(3):1176-1211
DS Docta Complutense
RD 15 sept 2025