RT Journal Article
T1 Ligilactobacillus salivarius PS2 Supplementation during Pregnancy and Lactation Prevents Mastitis: A Randomised Controlled Trial
A1 Jiménez, Esther
A1 Manzano Jiménez, Susana
A1 Schlembach, Dietmar
A1 Arciszewski, Krzysztof
A1 Martin, Rocio
A1 Ben Amor, Kaouther
A1 Roelofs, Mieke
A1 Knol, Jan
A1 Rodríguez, Juan Miguel
A1 Abou-Dakn, Michael
AB Mastitis is considered one of the main reasons for unwanted breastfeeding cessation. This study aimed to investigate the preventive effect of the probiotic strain Ligilactobacillus salivarius PS2 on the occurrence of mastitis in lactating women. In this multicountry, multicenter, randomized, double-blind, placebo-controlled trial, 328 women were assigned to the probiotic or the placebo group. The intervention started from the 35th week of pregnancy until week 12 post-partum. The primary outcome was the incidence (hazard) rate of mastitis, defined as the presence of at least two of the following symptoms: breast pain, breast erythema, breast engorgement not relieved by breastfeeding, and temperature > 38 °C. The probability of being free of mastitis during the study was higher in the probiotic than in the placebo group (p = 0.022, Kaplan–Meier log rank test) with 9 mastitis cases (6%) vs. 20 mastitis cases (14%), respectively. The hazard ratio of the incidence of mastitis between both study groups was 0.41 (0.190–0.915; p = 0.029), indicating that women in the probiotic group were 58% less likely to experience mastitis. In conclusion, supplementation of L. salivarius PS2 during late pregnancy and early lactation was safe and effective in preventing mastitis, which is one of the main barriers for continuing breastfeeding.
PB MPDI
SN 2076-2607
YR 2021
FD 2021-09-11
LK https://hdl.handle.net/20.500.14352/5031
UL https://hdl.handle.net/20.500.14352/5031
LA eng
NO Danone Nutricia Research, The Netherlands
DS Docta Complutense
RD 8 abr 2025