RT Journal Article
T1 Diadenosine Polyphosphates in Tears of Sjögren Syndrome Patients
A1 Carracedo Rodríguez, Juan Gonzalo
A1 Peral Cerda, María Asunción
A1 Pintor Just, Jesús Jerónimo
AB Purpose.: To analyze the levels of diadenosine tetraphosphate (Ap4A) and diadenosine pentaphosphate (Ap5A) in tears of subjects with Sjögren syndrome and to compare them with those in a control group.Methods.: Twelve subjects with a diagnosis of Sjögren syndrome and 20 healthy control subjects were invited to participate in the present study. Schirmer strips were used to measure tear secretion (Schirmer I test) and to collect tears. Ap4A and Ap5A were measured by high-pressure liquid chromatography (HPLC), and a dry eye questionnaire (DEQ) was used to evaluate dry eye symptomatology.Results.: The mean concentrations of Ap4A and Ap5A in the Sjögren syndrome group were 2.54 ± 1.02 and 26.13 ± 6.95 μM, respectively. This group of patients was divided in two subgroups: four patients with normal tear production and eight patients with low tear production. Concentrations of Ap4A, and Ap5A in patients with normal tear production (Schirmer test result, 12.3 ± 1.2 mm) were 0.47 ± 0.20 and 8.03 ± 3.27 μM, respectively. In the patients with low tear production (Schirmer test result, 1.0 ± 0.3 mm), the concentrations were 4.09 ± 1.36 and 39.51 ± 8.46 μM, respectively and in the control group, 0.13 ± 0.03 and 0.04 ± 0.02 μM, respectively.Conclusions.: Patients with Sjögren syndrome have abnormally elevated concentrations of diadenosine polyphosphates, indicating that these compounds could be used in the diagnosis of this disease.
PB The Association for Research in Vision and Ophthalmology, Inc.
SN 0146-0404
YR 2010
FD 2010-11
LK https://hdl.handle.net/20.500.14352/45154
UL https://hdl.handle.net/20.500.14352/45154
LA eng
NO Carracedo Rodríguez, G., Peral Cerda, M. A., Pintor Just, J. J. «Diadenosine Polyphosphates in Tears of Sjögren Syndrome Patients». Investigative Opthalmology & Visual Science, vol. 51, n.o 11, noviembre de 2010, p. 5452. DOI.org (Crossref), https://doi.org/10.1167/iovs.09-5088.
NO En O.A. en la web del editor
NO Banco Santander Central Hispano
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 6 abr 2025