RT Journal Article
T1 Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality
A1 Andreu-Ballester, Juan Carlos
A1 Pons-Castillo, Aurelio
A1 González-Sánchez, Antonio
A1 Llombart-Cussac, Antonio
A1 Cano Cebrián, María José
A1 Cuéllar Del Hoyo, María Del Carmen
A2 Zivkovic, Aleksandar R.
AB BackgroundLymphopenia is associated with various pathologies such as sepsis, burns, trauma, general anesthesia and major surgeries. All these pathologies are clinically expressed by the socalled Systemic Inflammatory Response Syndrome which does not include lymphopenia into defining criteria. The main objective of this work was to analyze the diagnosis of patients admitted to a hospital related to lymphopenia during hospital stay. In addition, we investigated the relationship of lymphopenia with the four levels of the Severity of Illness (SOI) and the Risk of Mortality (ROM).Method and findingsLymphopenia was defined as Absolute Lymphocyte Count (ALC) <1.0 x109/L. ALC were analyzed every day since admission. The four levels (minor, moderate, major and extreme risk) of both SOI and ROM were assessed. A total of 58,260 hospital admissions were analyzed. More than 41% of the patients had lymphopenia during hospital stay. The mean time to death was shorter among patients with lymphopenia on admission 65.6 days (CI95%, 57.3–73.8) vs 89.9 (CI95%, 82.4–97.4), P<0.001. Also, patients with lymphopenia during hospital stay had a shorter time to the mortality, 67.5 (CI95%, 61.1–73.9) vs 96.9 (CI95%, 92.6–101.2), P<0.001.ConclusionsLymphopenia had a high prevalence in hospitalized patients with greater relevance in infectious pathologies. Lymphopenia was related and clearly predicts SOI and ROM at the time of admission, and should be considered as clinical diagnostic criteria to define SIRS.
PB Public Library of Science
SN 1932-6203
YR 2021
FD 2021-08-13
LK https://hdl.handle.net/20.500.14352/101504
UL https://hdl.handle.net/20.500.14352/101504
LA eng
NO Andreu-Ballester JC, Pons-Castillo A, González-Sánchez A, Llombart-Cussac A, Cano MJ, Cuéllar C. Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality. PLoS One. 2021 Aug 13;16(8):e0256205. doi: 10.1371/journal.pone.0256205. PMID: 34388210; PMCID: PMC8362940.
DS Docta Complutense
RD 4 ago 2024