RT Journal Article
T1 Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum
A1 Valcárcel Olmeda, Ángela
A1 Briones Montero, Andrea
A1 Rodero Martínez, Marta
A1 González Fernández, Juan
A1 Olmeda García, Ángeles Sonia
A1 Valcárcel, Félix
A1 Cuéllar Del Hoyo, María Del Carmen
AB Alpha-Gal/α-Gal is an oligosaccharide produced by non-primate mammals. Humans have developed an immune response mediated by anti-α-Gal antibodies that can trigger an allergic reaction and cause anaphylaxis. In recent years, cases of patients with delayed allergic reaction to mammalian meat have been reported worldwide. In Spain, these cases have been related to the species Ixodes ricinus L. (Ixodida: Ixodidae), whose distribution is located in the north of the country. In this work, the presence of α-Gal in water-soluble extracts from samples of salivary glands and digestive tracts of Hyalomma lusitanicum Koch (Ixodida: Ixodidae) both engorged and collected from vegetation were studied. The presence of that epitope was confirmed by the presence of reactive proteins of >250 kDa in both samples. The highest concentrations of α-Gal were detected in salivary glands. Neither sex nor diet influenced the concentration of α-Gal, which seems to indicate its endogenous production and its possible inoculation to the host during tick feeding.
PB Wiley
SN 0269-283X
YR 2024
FD 2024-05-13
LK https://hdl.handle.net/20.500.14352/104412
UL https://hdl.handle.net/20.500.14352/104412
LA eng
NO Valcárcel, Á., Montero, A.B., Rodero, M., González-Fernández, J., Olmeda, A.S., Valcárcel, F. et al. (2024) Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum. Medical and Veterinary Entomology, 1–6. Available from: https://doi.org/10.1111/mve.12724
NO 2024 Acuerdos transformativos CRUE
DS Docta Complutense
RD 27 sept 2024