RT Journal Article
T1 Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
A1 Sola Vendrell, Emma
A1 Moyano-Cires Ivanoff, Paula Viviana
A1 Flores A, 
A1 García Sánchez, José Manuel
A1 García Lobo, Jimena
A1 Anadón Baselga, María José
A1 Frejo Moya, María Teresa
A1 Pelayo Alarcón, Adela
A1 Fernández Fernández, María De La Cabeza
A1 Pino Sans, Javier Del
AB Cadmium (Cd) produces cognition decline following single and repeated treatment, although the complete mechanisms are still unrevealed. Basal forebrain (BF) cholinergic neurons innervate the cortex and hippocampus, regulating cognition. Cd single and repeated exposure induced BF cholinergic neuronal loss, partly through thyroid hormones (THs) disruption, which may cause the cognition decline observed following Cd exposure. However, the mechanisms through which THs disruption mediate this effect remain unknown. To research the possible mechanisms through which Cd-induced THs deficiency may mediate BF neurodegeneration, Wistar male rats were treated with Cd for 1- (1 mg/kg) or 28-days (0.1 mg/kg) with or without triiodothyronine (T3, 40 μg/kg/day). Cd exposure promoted neurodegeneration, spongiosis, gliosis and several mechanisms related to these alterations (increased H202, malondialdehyde, TNF-α, IL-1β, IL-6, BACE1, Aβ and phosphorylated-Tau levels, and decreased phosphorylated-AKT and phosphorylated-GSK-3β levels). T3 supplementation partially reversed the effects observed. Our results show that Cd induces several mechanisms that may be responsible for the neurodegeneration, spongiosis and gliosis observed in the rats’ BF, which are partially mediated by a reduction in THs levels. These data may help to explain the mechanisms through which Cd induces BF neurodegeneration, possibly leading to the cognitive decline observed, providing new therapeutic tools to prevent and treat these damages.
PB Elsevier
SN 0009-2797
YR 2023
FD 2023-02-28
LK https://hdl.handle.net/20.500.14352/115389
UL https://hdl.handle.net/20.500.14352/115389
LA eng
NO Sola, E., Moyano, P., Flores, A., García, J. M., García, J., Anadon, M. J., Frejo, M. T., Pelayo, A., de la Cabeza Fernandez, M., & Del Pino, J. (2023). Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain. Chemico-biological interactions, 375, 110428. https://doi.org/10.1016/j.cbi.2023.110428
NO Author contribution statement:Emma Sola: Methodology, Investigation, Writing- Original draft preparation, Writing- Reviewing and Editing. Paula Moyano: Methodology, Investigation, Writing- Original draft preparation, WritingReviewing and Editing. Andrea Flores: Methodology, Investigation, Writing- Original draft preparation, Writing- Reviewing and Editing. Jimena García: Investigation, Writing- Original draft preparation, Writing- Reviewing and Editing. Jos´e Manuel García: Methodology, Investigation, Validation, Writing- Reviewing and Editing. Maria Jose Anadon: Methodology, Data curation, Writing- Reviewing and Editing. María Teresa Frejo: Formal analysis, Writing- Reviewing and Editing. Adela Pelayo: Resources, Formal analysis, Data curation, Supervision. Maria de la Cabeza Fernandez: Investigation, Writing- Reviewing and Editing. Javier Del Pino: Conceptualization, Methodology, Project administration, Supervision, Writing- Reviewing and Editing
NO Banco Santander
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 25 abr 2025